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Nebulizer formulation and production method thereof

An aerosol and dosage form technology, which is applied in the field of treating chronic obstructive pulmonary disease and asthma, and can solve problems such as unsuitability for budesonide sterilization

Inactive Publication Date: 2009-03-25
BREATH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] U.S. Patent Application 2003 / 0055026 discloses a method for the treatment of COPD, that is, aerosolized administration of a mixture of formoterol and budesonide, and mentions filter sterilization, but it is known from the international publication WO99 / 25359 that this Treatment for COPD not actually amenable to budesonide sterilization

Method used

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Embodiment Construction

[0015] Combined with the prior art, the present invention makes the use of the atomizing agent not limited by the lower limit of its volume. Formoterol, a beta agonist, is administered in a sterile dosage form together with budesonide, a steroid.

[0016] The active agent mentioned here also refers to pharmaceutically suitable derivatives, including but not limited to various salts, esters, enol ethers, enol esters, acids, bases, solvates, hydroxides or prodrugs thereof. Budesonide, a corticosteroid that reduces the frequency and severity of exacerbations of COPD / asthma, acts synergistically with formoterol to enhance bronchodilation. Therefore, the budesonide involved here not only includes but not limited to any form that can prevent the exacerbation of COPD, but also includes but not limited to all crystal forms, enantiomers, chiral isomers, acid anhydrides, acid salts, Basic salts, solvates, analogues or derivatives of budesonide.

[0017] A method for treating COPD or a...

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PUM

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Abstract

A sterile nebulizer formulation contains formoterol and budesonide in about 2ml or less of saline and is for treatment of COPD and asthma and other airways diseases and disorders.

Description

technical field [0001] The invention relates to an atomized dosage form, in particular to an atomized dosage form, a preparation method of the dosage form and a method for treating chronic obstructive pulmonary disease (COPD) and asthma with the dosage form. Background technique [0002] Nebulizers provide a means of delivering medication through the patient's airways at a near-normal breathing rate. Nebulizers are especially suitable for patients who cannot inhale the required dose more quickly through a metered dose inhaler or dry powder inhaler, whether because of age, injury or other reasons; Patients who are unable to coordinate their breathing rate with the rate at which the metered-dose inhaler works. The nebulizer produces a vapor containing drug particles, and the patient inhales the drug through a mouthpiece or a mask fitted to the nebulizer. Nebulizers are commonly used to administer medications to patients with respiratory disorders such as asthma or COPD. [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00
CPCA61K9/0078A61K31/167A61K31/58A61P11/00A61P11/06A61K2300/00A61K9/12A61K31/57A61K31/573
Inventor I·G·C·麦克阿弗P·E·塔什科
Owner BREATH
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