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Method for separation purification of isoleucine from isoleucine liquid

An isoleucine solution and isoleucine technology, which is applied in the field of high-purity isoleucine preparation, can solve the problems of low yield of isoleucine products, affect product quality, etc. The effect of low labor intensity and low production cost

Inactive Publication Date: 2009-02-18
WUXI GREEN SEPARATION TECH INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method cannot separate a large number of inorganic salts and heteroamino acids well
Seriously affect product quality, so that the yield of isoleucine product is not high

Method used

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  • Method for separation purification of isoleucine from isoleucine liquid
  • Method for separation purification of isoleucine from isoleucine liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1 synthetic resin: first synthesize two kinds of special resins (metal ion type chelating resin and acid radical ion type chelating resin) that are used for special adsorption and separation of isoleucine;

[0035] Metal ion-type chelating resins use acidic macroporous or gel resin as a carrier to chelate metal ions, and use the affinity between acidic resin and metal ions to adsorb metal ions on the surface of acidic macroporous or gel resin. And use a cross-linking agent to fix it on the carrier resin; the cross-linking agent used is 4% to 20% of the weight of the acidic macroporous or gel resin, and the best is 10% to 14%.

[0036] Metal ion is Al 3+ or Ba 2+ or Bi 3+ or Ca 2+ or Co 2+ or Co 3+ or Cu 2+ or Fe 2+ or Fe 3+ or K + or Mg 2+ or Na + or Ni 3+ or Pb 2+ or Sb 3+ or Sn 2+ or Zn 2+ , which is used in the form of a salt or oxide of a corresponding metal ion that can be dissolved under neutral or alkaline conditions, and the amount of ...

Embodiment 2

[0051] Embodiment 2 separation and purification:

[0052] The fixed bed equipped with the above-mentioned special resin is used to use the simulated moving bed technology to separate and purify isoleucine from the fermented liquid, ionized liquid or product mother liquor to obtain pure isoleucine products;

[0053] Simulated moving bed technology: the above-mentioned special resin is used as the stationary phase adsorbent in the simulated moving bed chromatographic separation device, and the affinity difference between the functional group and isoleucine and other impurities is used to realize the separation of isoleucine and protein, sugar, pigment , inorganic salts, and heteroamino acids; using water as the eluent, the separation temperature is 35°C to 95°C, and the optimum separation temperature is 70°C, and continuous feeding and discharging operations can obtain two types of compounds One is a component rich in isoleucine (the purity of isoleucine is 85% to 98%, generally...

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Abstract

The present invention relates to a method of separating and purifying isoleucine from isoleucine solution, and belongs to the technical field of analog mobile bed separation. In the method, two special types of resin which are in particular used for absorbing and separating isoleucine, namely, metal ion type chelated resin and acid radical ion type chelated resin, are synthesized at first; a fixed bed filled with the special resin adopts the simulation moving bed technology to separate and purify the isoleucine solution, so as to acquire the pure isoleucine product; the complete separation of the isoleucine, protein, sugar, pigment, inorganic salt and mixed amino acid can be basically realized through the continuous chromatographic separation of the moving bed; the utilization rate of the resin is high; the full automation of the production process is realized; the labor intensity is low; the production field is small; the production cost is low; only 1 to 2 m3 of water and a small amount of electricity are required for separation of each cubic meter of isoleucine; no chemical is required in the production process; and no pollution is generated.

Description

technical field [0001] The present invention relates to a preparation method of high-purity isoleucine, in detail, it relates to the clever use of special resin and simulated moving bed to separate and prepare high-purity isoleucine from isoleucine fermentation liquid, separation liquid or product mother liquor Sour methods and processes. The invention belongs to the technical field of simulated moving bed separation. Background technique [0002] L-isoleucine is also widely used in food and medicine. In terms of food, L-isoleucine is one of the essential amino acids for human and animal nutrition. The lack of L-isoleucine in the human body will lead to loss of appetite, physical decline, anemia and other dysfunctions. In terms of medicine, L-isoleucine is one of the three branched-chain amino acids. Because of its special structure and function, it has a particularly important position in the metabolism of human life. In addition to being used in general nutritional com...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/08C07C227/40B01D15/04B01J45/00
Inventor 俞铮彭奇均
Owner WUXI GREEN SEPARATION TECH INST
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