A preparation method of biocompatible vascular stent or heart valve surface coating
A biocompatible, vascular stent technology, applied in the field of biochemical modification, can solve the problems of increased vascular stent, social loss, poor anticoagulant function on the surface of the stent, etc.
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Embodiment 1
[0024] A preparation method of a vascular stent surface coating with good biocompatibility, the steps are:
[0025] A. Preparation of coating solution Dissolve heparin in deionized water, adjust its pH value to 7, and add endothelial cell growth factor to prepare a heparin / growth factor solution; the heparin concentration in the heparin / growth factor solution in this example 0.5mg / ml, endothelial cell growth factor concentration is 5ng / ml.
[0026] Collagen is dissolved in 0.2mol / L acetic acid solution to make a collagen solution, and the concentration of the collagen solution is 0.5mg / ml.
[0027] Before performing the dip-coating in the following step B, first immerse the vascular stent in a 0.5mol / L strong alkali solution at 60°C for 3 hours for activation; take it out, ultrasonically clean it with deionized water, and then immerse it in a 0.1mg / ml poly In the polylysine solution, soak for 1 hour, take out the deionized water to clean, blow dry with nitrogen, and then carr...
Embodiment 2
[0031] A method for preparing a heart valve surface coating with good biocompatibility, the steps are:
[0032] A. Preparation of coating solution Dissolve heparin in deionized water, adjust its pH value to 8, and add endothelial cell growth factor to prepare a heparin / growth factor solution; the heparin concentration in the heparin / growth factor solution is 25 mg / ml, the concentration of endothelial cell growth factor is 50ng / ml.
[0033] The collagen is dissolved in 0.2 mol / L acetic acid solution to prepare a collagen solution, and the concentration of the collagen solution is 5 mg / ml.
[0034]Before the dip coating of the following step B, the heart valve is first activated by immersing it in a 5mol / L strong alkali solution at 80°C for 24 hours; take it out, ultrasonically clean it with deionized water, and then immerse it in 10mg / ml polymer In the lysine solution, soak for 12 hours, take out the deionized water to clean, blow dry with nitrogen, and then carry out the dip...
Embodiment 3
[0038] A preparation method of a vascular stent surface coating with good biocompatibility, the steps are:
[0039] A. Preparation of coating solution Dissolve heparin in deionized water, adjust its pH value to 7.5, and add endothelial cell growth factor to obtain a heparin / growth factor solution; the heparin concentration in the heparin / growth factor solution is 5mg / ml, the concentration of endothelial cell growth factor is 10ng / ml.
[0040] The collagen is dissolved in 0.2 mol / L acetic acid solution to prepare a collagen solution, and the concentration of the collagen solution is 1 mg / ml.
[0041] Before the dip-coating of the following step B, the stent is activated by immersing it in a 3mol / L strong alkali solution at 70°C for 10 hours; take it out, ultrasonically clean it with deionized water, and then immerse it in 2mg / ml polymer In the lysine solution, soak for 4 hours, take out the deionized water to clean, blow dry with nitrogen, and then carry out the dip coating i...
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