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Use of traditional Chinese medicine in preparing medicine for treating diabetes cardiomyopathy

A technology of composition and traditional Chinese medicine, applied in the direction of drug combination, drug delivery, active ingredients of hydroxyl compounds, etc., can solve problems such as undisclosed traditional Chinese medicine composition

Inactive Publication Date: 2009-02-11
HEBEI YILING MEDICINE INST
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The above two patents do not disclose the application of the traditional Chinese medicine composition in the treatment of diabetic cardiomyopathy

Method used

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  • Use of traditional Chinese medicine in preparing medicine for treating diabetes cardiomyopathy
  • Use of traditional Chinese medicine in preparing medicine for treating diabetes cardiomyopathy
  • Use of traditional Chinese medicine in preparing medicine for treating diabetes cardiomyopathy

Examples

Experimental program
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Effect test

Embodiment 1

[0065] a) The raw material drug formula is:

[0066] Ginseng 39.6g Leech 72.6g Wood Beetle 46.2g Frankincense (made) 13.2g

[0067] Paeoniae Rubra 33g Dalbergia 13.2g Sandalwood 13.2g Scorpio 19.8g

[0068] Cicada slough 46.2g centipede 6.6g borneol 33g Suanzaoren (fried) 33g;

[0069] b) Crushing process of medicinal materials:

[0070] The scorpion, leech, centipede, ground beetle, and cicada slough five kinds of insect medicines have been cleaned, washed and processed, and the frankincense prepared after cleaning is prepared according to the prescription, and crushed by a pulverizer, and the fineness of the powder reaches more than 80 mesh; The powdered medicine is ultrafinely pulverized by various ultrafine pulverization techniques, so that the average particle size of the medicine powder is less than 30-40 μm; the medicinal materials to be pulverized are washed, dried and sterilized, and the ingredients are prepared;

[0071] c) Extraction concentration and drying proc...

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Abstract

The invention discloses a traditional Chinese medicine composition applied to preparing medicines for curing diabetes cardiomyopathy. Tests prove that the pharmaceutical composition can enhance the activity of suckling mouse cardiac muscle cells in vitro culture; by promoting the expression of mRNA of superoxide dismutase (SOD2), free radicals are eliminated and high-glucose-induced myocardial cell injury is prevented by restraining oxidative stress; simultaneously, the medicinal composition can improve myocardial lesions of a diabetes rat model and restrain cardiac muscle cell apoptosis; gene chip test results show that the medicinal composition plays the roles of curing the diabetes cardiomyopathy in the aspects of correcting sugar and protein metabolism, enhancing antioxidant capacity, inhibiting cell apoptosis and the like; and the experimental results prompt that the medicinal composition can protect the cardiac muscle of a patient and cure the diabetes cardiomyopathy.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine composition. Specifically, the present invention relates to the application of a traditional Chinese medicine composition in the preparation of medicine for treating diabetic cardiomyopathy, which belongs to the field of traditional Chinese medicine application. Background technique [0002] Diabetic cardiomyopathy (DC) refers to a disease state in which the primary injury of cardiomyocytes in diabetic patients causes extensive structural abnormalities, eventually leading to ventricular hypertrophy, diastolic and / or systolic dysfunction [Sajad A, Billal, Rajdeep S, et al. Diabetic cardiomyopathy: mechanism, diagnosis and treatment. Clin Sci, 2004, 107: 539-557. (Diabetic cardiomyopathy: mechanism, diagnosis and treatment. Clinical Science, 2004, 107: 539-557. )], which was first proposed by Rubler in 1972. In recent years, a large number of studies have confirmed that diabeti...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P3/10A61P9/00A61P43/00A61K31/045A61K35/62A61K35/64
Inventor 吴以岭
Owner HEBEI YILING MEDICINE INST
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