Novel technique for preparing 4-formyl amino antipyrine

Abstract

The invention provides a new technique for preparing intermediate 4-formyl amino antipyrine. Antipyrine carries out a plurality of technique steps, including nitrosation, reduction, hydrolysis, neutralization and acylation. The new technique is characterized in that: 4-formyl amino antipyrine hydrolysate which is obtained after the nitrosation, reduction and hydrolysis carries out colloid treatment, neutralization and acylation reaction to prepare 4-formyl amino antipyrine. The colloid impurity treatment includes the steps: extractant is added into 4-amino antipyrine hydrolysate, and colloid impurity is removed after extracting. The new technique for preparing 4-formyl amino antipyrine hydrolysate improves the quality of analgin intermediate greatly, reduces the labor intensity and production cost greatly, simplifies production technical process, improves production efficiency, saves energy and reduces consumption, saves workshop equipment, and brings considerable economic benefit forthe enterprises.

Description

technical field [0001] The invention relates to a chemical synthesis preparation process, in particular to a preparation process of analgin intermediate 4-formylaminoantipyrine, an antipyretic and analgesic drug. Background technique [0002] Analgin is mainly used for reducing fever, and is also used to treat acute arthritis, headache, rheumatic pain, toothache and muscle pain, etc. [0003] The synthesis of Analgin uses pyrazolone as the starting material to produce antipyrine, which then produces 4-aminoantipyrine, and 4-aminoantipyrine then produces 4-formyl Aminoantipyrine and 4-formylaminoantipyrine are then produced into 4-methylaminoantipyrine, and 4-methylaminoantipyrine is condensed to produce the finished product Analgin. [0004] Wherein 4-formylaminoantipyrine is one of the important intermediates of synthetic Sulpyrine, but due to the process of synthesizing Sulpyrine intermediate antipyrine and 4-aminoantipyrine, it needs to go through high temperature And p...

AI Technical Summary

Problems solved by technology

This treatment method is a physical separation method, the separation of the feed liquid and the colloid is not complete, the colloid contains the material, and the feed liquid also contains the remaining colloid, which seriously affects the quality of the intermediate in the subsequent process and the quality of the finished product, and wastes a lot of materials.

At the same time, this treatment method has a long process flow, cumbersome operation, low production efficiency, high energy consumption, and high raw material cost.

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