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Preparation method of functional microsphere with light/temperature/magnetism multiple response

A technology of responsiveness and microspheres, applied in the field of preparation of functional microspheres, which can solve the problems of less reports on triple responsive functional microspheres

Inactive Publication Date: 2011-06-22
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the current literature reports are functional microspheres with dual stimulus responsiveness, and there are few reports on functional microspheres with triple responsiveness.

Method used

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  • Preparation method of functional microsphere with light/temperature/magnetism multiple response

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Example 1: In a 100mL three-necked bottle, 50mL of an aqueous solution of 100mg of magnetic silica microspheres modified with a double bond was added, 160mg of N-isopropylacrylamide (NIPAM), 160mg of NIPAM, aminoethyl methacrylate ( AEMA) 40mg and N, N'-methylenebisacrylamide monomer (MBA) 2.0mg, in N 2 Under the conditions, the temperature was raised to 65-75°C, and after 0-1 hour of stabilization, 10 mg of initiator potassium persulfate was added, and the reaction was completed after 4-6 hours. The resulting product was washed with water by repeated centrifugation to remove unreacted monomers, and then freeze-dried to remove water.

[0012] The lyophilized product was redispersed into 40 mL of N, N-dimethylformamide (DMF) solvent under high-speed stirring, and then 72.7 mg of catalyst triethylamine and 64.8 mg of photosensitive molecule 2-diazo were dissolved. - 5 mL of DMF solution of 1-naphthoquinone-5-sulfonyl chloride, after 3-5 hours of reaction in the dark, the...

Embodiment 2

[0013] Example 2: In a 100mL three-necked bottle, 50mL of an aqueous solution of 100mg of magnetic silica microspheres modified with a double bond was added, 520mg of N-isopropylacrylamide (NIPAM), methacrylate aminoethyl ( AEMA) 40mg and N, N'-methylenebisacrylamide monomer (MBA) 5.6mg, in N 2 Under the conditions, the temperature was raised to 65-75°C, and after 0-1 hour of stabilization, 28 mg of initiator potassium persulfate was added, and the reaction was completed after 4-6 hours. The resulting product was washed with water by repeated centrifugation to remove unreacted monomers, and then freeze-dried to remove water.

[0014] The lyophilized product was re-dispersed in 40 mL of N, N-dimethylformamide (DMF) solvent under high-speed stirring, and then 87.3 mg of catalyst triethylamine and 194.5 mg of photosensitive molecule 2-diazo were dissolved. - 5 mL of DMF solution of 1-naphthoquinone-5-sulfonyl chloride, after 3-5 hours of reaction in the dark, the obtained produc...

Embodiment 3

[0015] Example 3: In a 100mL three-necked bottle, 50mL of an aqueous solution of 100mg of magnetic silica microspheres modified with a double bond was added, and 720mg of N-isopropylacrylamide (NIPAM) and aminoethyl methacrylate ( AEMA) 40mg and N, N'-methylenebisacrylamide monomer (MBA) 7.6mg, in N 2 Under the conditions, the temperature was raised to 65-75°C, and after being stable for 0-1 hour, 45.6 mg of initiator potassium persulfate was added, and the reaction was completed after 4-6 hours. The resulting product was washed with water by repeated centrifugation to remove unreacted monomers, and then freeze-dried to remove water.

[0016] The lyophilized product was redispersed into 40 mL of N,N-dimethylformamide (DMF) solvent under high-speed stirring, and then 14.5 mg of catalyst triethylamine and 13.0 mg of photosensitive molecule 2-diazo were added. - 5 mL of DMF solution of 1-naphthoquinone-5-sulfonyl chloride, after 3-5 hours of reaction in the dark, the obtained pr...

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Abstract

The invention belongs to the technical field of functional polymer materials, which particularly relates to a preparation method of a functional microsphere with multiple responsiveness of light / temperature / magnetism. The surface of a magnetic silica microsphere is coated with a polymer shell with temperature responsiveness and an amino functional group by precipitation polymerization, and then triethylamine is taken as a catalyst to catalyze the reaction between the amino and photosensitive molecule 2-diazo-1-naphthoquinone-5-sulfonyl chloride, therefore, a certain amount of photosensitive groups are modified on the surface of the polymer shell of the microsphere, and finally the functional microsphere with multiple responsiveness of light / temperature / magnetism is obtained. The preparation method has the advantages that the method is simple, the raw materials are easily available the prepared functional microsphere has good dispersibility in water, and the size of the microsphere canbe controlled. The functional microsphere prepared by the method of the invention can respond to various external stimulations, can be used as a drug carrier, and realizes target controlled release of a drug.

Description

technical field [0001] The invention belongs to the technical field of functional polymer materials, and in particular relates to a preparation method of functional microspheres with light / temperature / magnetism multiple responsiveness. Background technique [0002] Stimuli-responsive functional microspheres are a class of "smart materials" that have special functions and are widely used as drug carriers. They can respond to external stimuli, such as temperature, ionic strength, pH value and magnetic field, etc. make a sharp response, so as to realize the controlled release of the drug at a fixed point. In recent years, more studies have been made on magnetic targeting functional microspheres and environmental response (light, pH, temperature, etc.) functional microspheres. Among these stimuli, temperature is the most widely used external stimuli. Changing the temperature is not only easy to control, but also can be conveniently applied in vivo and in vitro. Photostimulatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/02A61K9/50
Inventor 于媛媛汪长春
Owner FUDAN UNIV
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