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Solanum nigrum extract, preparation method and use thereof

An extract and technology of Solanum nigrum, applied in the field of Solanum nigrum extract, its preparation and its medicinal application, can solve the problems of high-efficiency pharmaceutical compositions, low content of active ingredients, and limited use, etc., and achieve strong production practicability, The effect of high content of active ingredients and low environmental pollution

Active Publication Date: 2009-01-07
上海硕方医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The currently used Solanum nigrum extraction method has high cost, low active ingredient content, more impurities, and relatively large pollution during the preparation process
The content of the active ingredients of the product obtained after extraction limits its use in pharmaceutical compositions, and cannot meet the needs of high-efficiency pharmaceutical compositions

Method used

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  • Solanum nigrum extract, preparation method and use thereof
  • Solanum nigrum extract, preparation method and use thereof
  • Solanum nigrum extract, preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Preparation of nightshade extract:

[0043] (1) 400g whole Solanum herb, add 2000ml 90% ethanol, reflux and extract 3 times, 1.5 hours each time;

[0044] (2) Recover ethanol from the extract until it has no alcohol taste, and obtain a concentrated solution of about 300ml. Petroleum ether extracts 3 times, with a dosage of 300ml each time;

[0045] (3) The concentrated solution is treated with 400ml of HD-8 strong acid cation exchange resin (Shanghai Huazhen Technology Co., Ltd.) which is processed into H+ type for column adsorption, and then eluted with water until the effluent is nearly colorless, and eluted with 400ml of 40% ethanol. Elute with 800ml of 90% ethanol, elution with 1200ml of ammonia-containing ethanol (90% ethanol: 25% ammonia is 10:1);

[0046] (4) Collect the eluted part of ethanol containing ammonia and recover the ethanol;

[0047] (5) Centrifuge the concentrated solution at 5000 rpm for 10 minutes, and discard the supernatant;

[0048](6) Wash the prec...

Embodiment 2

[0051] Preparation of nightshade extract:

[0052] (1) 1000g of nightshade fruit, add 5000ml of 90% ethanol, reflux and extract 3 times, 1.5 hours each time;

[0053] (2) Recover ethanol from the extract until it has no alcohol taste, and get about 800ml of concentrated solution;

[0054] (3) The concentrated solution is treated with 1000ml of HD-8 strong acid cation exchange resin (Shanghai Huazhen Technology Co., Ltd.) which is processed into H+ type, and then it is eluted with water until the effluent is nearly colorless, and eluted with 1000ml of 40% ethanol. Elute with 2000ml of 90% ethanol, elution with 3000ml of ammonia-containing ethanol (90% ethanol: 25% ammonia water is 10:1);

[0055] (4) Collect the eluted part of ethanol containing ammonia and recover ethanol;

[0056] (5) Centrifuge the concentrated solution at 5000 rpm for 10 minutes, and discard the supernatant;

[0057] (6) Wash the precipitate with a small amount of water, centrifuge at 5000 rpm for 10 minutes, w...

Embodiment 3

[0060] Preparation of nightshade extract:

[0061] (1) 400g of whole Solanum herb, add 2000ml of 90% ethanol, and ultrasonically extract 3 times, 1.5 hours each time;

[0062] (2) Recover ethanol from the extract liquid until it has no alcohol taste, and obtain a concentrated liquid of about 300ml, which is extracted 3 times with petroleum ether, and the dosage is 300ml each time;

[0063] (3) The concentrated solution is treated with 400ml of HD-8 strong acid cation exchange resin (Shanghai Huazhen Technology Co., Ltd.) which is processed into H+ type for column adsorption, eluted with water until the effluent is nearly colorless, and eluted with 400ml of 40% ethanol. Elution with 800ml of 90% ethanol, 1200ml of 80% ethanol with 0.1% sodium hydroxide;

[0064] (4) Collect the ethanol eluted part containing sodium hydroxide and recover the ethanol;

[0065] (5) Centrifuge the concentrated solution at 5000 rpm for 10 minutes, and discard the supernatant;

[0066] (6) Wash the preci...

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Abstract

The invention relates to a solanum nigrum extractive, the preparation method and the medicament application thereof, wherein, the total content of solancarpine, solamargine and solasurine is 80wt% to 99wt%; the content of solancarpine is 30wt% to 50wt%; the content of solamargine is 10wt% to 30wt%; and the content of solasurine is 30wt% to 50wt%. The invention further relates to the preparation method of the solanum nigrum extractive and the application with the solanum nigrum extractive being the active components in the medicaments for preventing and curing diseases, such as tumor, diabetes, asthma, coronary heart disease, etc.

Description

Technical field [0001] The invention relates to a plant solanum extract, its preparation method, and its application as an active ingredient to prepare medicines for preventing and treating tumors, diabetes, asthma, coronary heart disease and other diseases. Background technique [0002] Solanum Solalum Nigrum L. is an annual herbaceous plant of the genus Solanum, which grows in most provinces in China. The whole herb is used for medicinal purposes. It is cold in nature, bitter and pungent in taste, slightly sweet, and has a small poison. It can dissipate blood stasis and reduce swelling, clear heat and detoxify. It has strong antibacterial effect on Staphylococcus aureus, typhoid bacillus, dysentery bacillus, Proteus, Escherichia coli, Pseudomonas aeruginosa, and cholera bacillus suis. It has the effect of inhibiting cancer cells, urinary system infection and leucorrhea. It is commonly used to treat carbuncle , Tumors, dysentery, etc., folk use for the treatment of diabetes has ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61K31/58A61P3/10A61P9/10A61P11/06A61P35/00A61K131/00B01J39/04
Inventor 王妍秦继红
Owner 上海硕方医药科技有限公司
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