Polylactic acid medical thin-film material with low plasticiser mobility and preparation method thereof

A technology for plasticizing polylactic acid and film materials, applied in medical science, surgery, etc., can solve the problems of complex polymer plasticizers, achieve the effects of reduced mobility, inhibited migration, and increased elongation at break

Inactive Publication Date: 2008-12-31
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent CN1857235 discloses plasticizing and modifying polylactic acid by replacing small molecule medical plasticizers with polymeric polymeric plasticizers, so as to solve the problem of small molecule migration, but the highest elongation at break of polylactic acid films is only 140%. , and this method is relatively complicated to prepare polymeric plasticizers

Method used

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  • Polylactic acid medical thin-film material with low plasticiser mobility and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Mix common medical plasticizer tri-n-butyl citrate (TEC) and chain extender J-ADR 4370S in a mass ratio of 100:0.5 in a reaction bottle, heat in an oil bath at 150°C, and accompany magnetic stirring for 2 hour, the reaction product obtained is the modified medical plasticizer; with 15 parts by weight of this modified medical plasticizer, 85 parts by weight of pure polylactic acid vacuum-dried in the torque rheometer, at 150 ℃, the rotating speed is Melt processing at 32rpm for 3 minutes, melt processing at 64rpm for 2 minutes, and then hot pressing at 160°C and 15MPa pressure for 5 minutes and cold pressing for 5 minutes in a hot press molding machine to form a thin plate. Its performance is shown in Table 1.

Embodiment 2

[0033] Common medical plasticizer tri-n-butyl citrate (TBC) and chain extender J-ADR 4370S were mixed in a reaction bottle at a mass ratio of 100:0.5, heated in an oil bath at 145°C, and accompanied by magnetic stirring for 2 hour, the reaction product obtained is the modified medical plasticizer; with 15 parts by weight of this modified medical plasticizer, 85 parts by weight of pure polylactic acid vacuum-dried in the torque rheometer, at 150 ℃, the rotating speed is Melt processing at 32rpm for 3 minutes, melt processing at 64rpm for 2 minutes, and then hot pressing at 160°C and 15MPa pressure for 5 minutes and cold pressing for 5 minutes in a hot press molding machine to form a thin plate. Its performance is shown in Table 1.

Embodiment 3

[0035] Common medical plasticizer tri-n-butyl citrate (TBC) and chain extender J-ADR 4368CS were mixed in a reaction bottle at a mass ratio of 100:0.6, heated in an oil bath at 145°C, and accompanied by magnetic stirring for 2 hour, the reaction product obtained is the modified medical plasticizer; with 15 parts by weight of this modified medical plasticizer, 85 parts by weight of pure polylactic acid vacuum-dried in the torque rheometer, at 150 ℃, the rotating speed is Melt processing at 32rpm for 3 minutes, melt processing at 64rpm for 2 minutes, and then hot pressing at 160°C and 15MPa pressure for 5 minutes and cold pressing for 5 minutes in a hot press molding machine to form a thin plate. Its performance is shown in Table 1.

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Abstract

The invention relates to a medical film material and a preparation method thereof for the plasticized polylactic acid of low plasticizer mobility. The composition of the material is as follows by weight portion: 75 to 95 portions of polylactic acid; and 5 to 25 portions of modified medical plasticizer. The preparation method thereof is as follows: a general medical plasticizer and a chain extender are mixed in oily bath to get a modified medical plasticizer through reaction, then the polylactic acid and the modified medical plasticizer are melt and blended in a torque rheometer and hot-pressed under the pressure of 10 to 20 MPa, and later a medical film material for the plasticized modified polylactic acid of low plasticizer mobility is gotten through cold pressure molding. The medical film material for the polylactic acid through the modification of the novel medical plasticizer has lower plasticizer mobility, excellent flexibility, high elastic modulus and fracture strength and good biochemical property, can be used for the field of medical package and so on, and completely solves the problem of white pollution, thereby producing huge economic and social benefits.

Description

technical field [0001] The invention relates to a biodegradable plasticized polylactic acid medical film material with low plasticizer mobility and a preparation method thereof, belonging to the technical field of polylactic acid film materials. Background technique [0002] Polylactic acid (PLA) is a synthetic linear aliphatic polyester, which is a synthetic polymer that is completely biodegradable in nature. Its synthetic monomer lactic acid is widely derived from agricultural products, and the degradation products are water and carbon dioxide which are harmless to the environment. The material has good mechanical strength, thermoplasticity, fibrillation and transparency, and is suitable for a variety of processing methods. It is considered by the industry to be the most promising new material in the new century. At present, the production line of polylactic acid in the world has Nature of the United States. Works' 140,000-ton / year production line is currently the world's...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/14C08L67/04C08L25/08
Inventor 尹静波鲁晓春王尹杰李孝秀杨艳颜世峰陈学思
Owner SHANGHAI UNIV
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