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Solid preparation containing ibuprofen, tranexamic acid and calcium silicate

A technology of tranexamic acid and calcium silicate, which is applied in the direction of medical preparations containing active ingredients, medical preparations without active ingredients, anti-inflammatory agents, etc., can solve the problem of small analgesic effect and achieve convenient use Effect

Inactive Publication Date: 2008-12-31
KOWA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since ibuprofen has side effects such as gastrointestinal disturbances, and its analgesic effect is small, it has been studied in combination with various drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 900 g of ibuprofen (manufactured by Yonezawa Hamari: brand name Japanese Pharmacopoeia ibuprofen), tranexamic acid 1,499.4 g (manufactured by Daiichi Sankyo Profile: brand name Japanese Pharmacopoeia tranexamic acid), 549 g of calcium silicate (manufactured by エザイフードデミカル: trade name Fluorite RE), 106.2 g of hydroxypropyl cellulose, 1348.2 g of crystalline cellulose, and 360 g of croscarmellose sodium are put into a high-speed stirring granulator (manufactured by Fukae Industry Co., Ltd. : FS-10 type) After mixing, add 466g of purified water and knead. The granulated material was put into a fluidized bed dryer (manufactured by Floint Industries: Model FLO-5) and dried, and then sized by a granulator (manufactured by Okada Seiko: ND-10). 4762.8 g of the whole granules and 97.2 g of magnesium stearate were put into a mixer (manufactured by Kotobuki: PM50 type) and mixed, and then a tablet press equipped with a punch with a diameter of 8.5 mm ( Manufactured by Tetsuko Wor...

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PUM

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Abstract

The invention provides a solid preparation with restrained expansion under high temperature preservation condition, containing ibuprofen and tranexamic acid. The solid preparation containing ibuprofen and tranexamic acid is characterized in that the solid preparation contains calcium silicate.

Description

technical field [0001] The present invention relates to a solid preparation comprising ibuprofen and tranexamic acid whose swelling is inhibited under high-temperature storage conditions. Background technique [0002] Ibuprofen is widely used as a non-steroidal anti-inflammatory drug (NSAID), anti-inflammatory and analgesic for chronic joint rheumatism, joint pain and arthritis, neuralgia and neuritis, low back pain and other diseases and symptoms Effective, in addition to cold syndrome, acute bronchitis, acute exacerbation of chronic bronchitis anti-inflammatory and antipyretic, etc. are also effective. However, since ibuprofen has side effects such as gastrointestinal disturbances and has a small analgesic effect, a combination preparation with various drugs has been studied. [0003] For example, antipyretic analgesics in which ibuprofen is mixed with aniline derivative antipyretic analgesics such as busetin (see Patent Document 1), and preparations in which ibuprofen is...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/192A61K31/195A61K47/04A61P29/00
CPCA61K47/02A61K9/20A61K31/192A61K31/195A61K2300/00
Inventor 薄井俊树
Owner KOWA CO LTD
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