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Preparation method for ursolic acid, produced products and application thereof

A technology of ursolic acid and microfilm, which is applied to medical preparations containing active ingredients, pharmaceutical formulations, respiratory system diseases, etc. The effect of less loss, simple process flow and lower extraction cost

Inactive Publication Date: 2008-12-10
谢佳良
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technological process of above-mentioned method extracting ursolic acid is more complicated, and ethanol consumption is big, and washing three times makes active ingredient loss big, and the yield of ursolic acid has only about 60%, and the energy consumption of twice drying is more, thereby increased cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1 of the present invention: extract ursolic acid from loquat leaf according to the following steps:

[0019] Get 10 kilograms of loquat leaves and pulverize them to 15-20 meshes, put them into an extraction tank, add 50 kilograms of 95% edible ethanol, and perform ultrasonic extraction for 1.5 hours. 0.2MPa, the temperature of the feed liquid is 28°C; the filtrate is supplied by a pump with an ultrafiltration membrane with a molecular weight of 5,000 to 10,000 for preliminary purification and separation, and its working pressure is 0.4MPa, and the temperature is 28°C to remove the macromolecular part in the solution; The filtrate is then purified and separated by a nanofiltration membrane with a molecular weight of 800-2000. The working pressure is 1.5MPa and the temperature is 28°C. The liquid passing through the nanofiltration membrane is a mixture of ethanol and ursolic acid, and the ethanol is recovered by vacuum , that is, ursolic acid, and its dry yield...

Embodiment 2

[0020] Embodiment 2 of the present invention: prepare ursolic acid according to the following steps:

[0021] Get 5 kilograms of loquat leaves and pulverize them to 15-20 meshes, add 50 kilograms of 95% ethanol, and conduct ultrasonic extraction for 0.5 hours. ℃; the filtrate is initially purified and separated with an ultrafiltration membrane with a molecular weight of 5,000 to 10,000, the working pressure is 0.2 MPa, and the temperature is 30°C to remove the macromolecular part in the solution; The nanofiltration membrane is used for purification and separation. The operating pressure is 0.5 MPa and the temperature is 25° C. The liquid passing through the nanofiltration membrane is a mixture of ethanol and ursolic acid. The ethanol is recovered to obtain ursolic acid with a yield of 75%.

Embodiment 3

[0022] Embodiment 3 of the present invention: the preparation of Momordica grosvenori honey cream: get 24.9 grams of mogrosides, 75 grams of honey and 0.1 gram of ursolic acid obtained in embodiment 1, mix, stir for 25~30 minutes and make it mix evenly, namely Get Luo Han Guo honey paste.

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Abstract

The invention discloses a method for preparing ursolic acid and a product and an application thereof. The method comprises the following steps that: loquat leaves are pulverized, added with 95 percent ethanol and subjected to ultrasonic extraction for 0.5 to 2 hours; an extractant is filtered by a micromembrane; a filtrate is separated by an ultrafiltration membrane and a nanofiltration membrane to produce a mixed solution of the ethanol and the ursolic acid; the ethanol is reclaimed, and the ursolic acid is obtained; the obtained ursolic acid is mixed with grosvener siraitia and honey to prepare grosvener siraitia honey cream. The invention adopts a method of combining ultrasonic extraction and membrane separation and purification, and extracts the ursolic acid from the loquat leaves; the method has relatively simple process flow, small loss of effective compositions, an ursolic acid yield of more than 75 percent, small ethanol amount and low energy consumption, thereby reducing extraction cost; and the prepared grosvener siraitia honey cream has the faint scent and sweetness of the grosvener siraitia and the light fragrance, fresh and sweet taste and mellowness of the honey, and has the functions of sedation, heat-clearing and lung-moistening, intestine moistening, defaecation and sleep improvement, thereby becoming a high-quality health-care product integrating nutrition and health care.

Description

(1) Technical field: [0001] The invention relates to a preparation method of ursolic acid and its product and application, and belongs to the technical field of extraction and application of natural medicinal active ingredients. (two) background technology: [0002] Loquat leaves are the leaves of the Rosaceae Loquat plant Loquat. The main components contained are volatile oil, picralin, saponin, ursolic acid, oleanolic acid, vitamin B1 and c, tannins, organic acids, etc. Among them, ursolic acid (molecular formula: C 30 h 48 o 3 , molecular weight: 456.68) content in dried loquat leaves is about 1%. Ursolic acid has various biological effects such as sedative, anti-inflammatory, antibacterial, anti-diabetic, anti-ulcer, and lowering blood sugar. In recent years, it has been found that it has anti-carcinogenic, anti-cancer, induction of F9 teratoma cell differentiation and anti-angiogenesis effects, and it is very likely to become a new type of anticancer drug with low t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00A61K35/64A61K31/56A61K9/06A61P25/00A61P11/00A61K35/644
Inventor 谢佳良
Owner 谢佳良
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