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Composition for use in prevention of hypoglycemic condition

A composition and hypoglycemic technology, applied in the direction of drug combination, application, food preparation, etc., can solve unrecorded problems

Inactive Publication Date: 2008-10-15
OTSUKA PHARM FAB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] (2) The side effects of a certain drug;
However, none of these documents describe the promotion of sugar uptake by brain cells or the suppression of hypoglycemia symptoms

Method used

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  • Composition for use in prevention of hypoglycemic condition
  • Composition for use in prevention of hypoglycemic condition

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0087] Dissolve 300 g of L-isoleucine in distilled water for injection, then adjust the pH to 6.50 with sodium hydroxide, and further add distilled water for injection to adjust the total volume to 10 L. The resulting solution was filtered through a membrane filter, filled into polyethylene infusion bags at a rate of 500 mL / bag, sealed, and autoclaved at 105° C. for 40 minutes. The bag was packaged together with a deoxidizer (trade name: Ageless, manufactured by Mitsubishi Gas Chemical Co., Inc.) in a gas barrier packaging material made of a polyvinyl alcohol multilayer film to obtain an injection.

preparation Embodiment 2

[0089] 150 g of L-isoleucine and 150 g of L-valine were dissolved in distilled water for injection, then adjusted to pH 6.50 with sodium hydroxide, and distilled water for injection was further added to adjust the total volume to 10 L. The obtained solution was filtered through a membrane filter, filled into polyethylene infusion bags at a rate of 500 mL / bag, sealed, and autoclaved at 105° C. for 40 minutes. The bag was packaged together with a deoxidizer (trade name: Ageless, manufactured by Mitsubishi Gas Chemical Co., Inc.) in a gas barrier packaging material made of a polyvinyl alcohol multilayer film to obtain an injection.

preparation Embodiment 3

[0091] Dissolve 300 g of L-isoleucine in distilled water for injection, then adjust the pH to 6.50 with sodium hydroxide, further add distilled water for injection to adjust the total volume to 10 L, and filter through a membrane filter.

[0092] On the other hand, 1000 g of glucose was dissolved in distilled water for injection, then distilled water for injection was added to adjust the total volume to 10 L and filtered through a membrane filter.

[0093] Take 500 mL of each of these solutions and fill them in the chambers of two-chamber infusion bags made of polyethylene, one solution in each chamber, seal them, and perform high-pressure steam sterilization at 105° C. for 40 minutes. The bag was packaged together with a deoxidizer (trade name: Ageless, manufactured by Mitsubishi Gas Chemical Co., Ltd.) in a gas barrier packaging material made of a polyvinyl alcohol multilayer film to obtain an injection.

[0094] When using the injection, one of the chambers or two chambers ...

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PUM

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Abstract

Disclosed is a composition for use in the prevention of a hypoglycemic condition, which comprises at least one compound selected from a branched amino acid, a pharmaceutically acceptable salt thereof and a derivative of the amino acid or salt as an active ingredient. The composition can promote the uptake of a saccharide into a brain cell to thereby prevent a hypoglycemic condition.

Description

technical field [0001] The present invention relates to a composition for suppressing hypoglycemia symptoms or an accelerator for brain cell uptake of carbohydrates, the composition or accelerator containing branched-chain amino acids, pharmaceutically acceptable salts thereof, or derivatives thereof as active ingredients. Background technique [0002] Symptoms of hypoglycemia refer to the reduction of glucose level in the blood and the reduction of glucose level in the brain, resulting in fatigue, general malaise, restlessness, burnout, nervousness, trembling, headache, weakness, cold sweat and Symptoms of palpitations, further causing disturbance of consciousness and coma, may also lead to death in severe cases. [0003] The main causes of hypoglycemia include the following: [0004] (1) Excessive administration of hypoglycemic drugs (insulin, etc.) to diabetic patients; [0005] (2) The side effects of a certain drug; [0006] (3) Eating habits of long-term and continu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61K31/7004A61P25/00A61P25/02A61P43/00A23L21/10A23L33/00
CPCA61K31/198A23L1/3051A23L1/3053A23V2002/00A61K9/0019A61K9/0095A61K31/7004A23L33/175A23L33/18A61P3/02A61P3/08A61P25/00A61P25/02A61P43/00A61K2300/00A23V2200/328A23V2250/0626A23V2250/0628A23V2250/0654A23V2200/322
Inventor 土居雅子山冈一平
Owner OTSUKA PHARM FAB INC
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