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Atomizing grippe vaccine composition and preparation thereof

A technology for vaccine composition and influenza, which is applied in the direction of non-active ingredients of polymer compounds, pharmaceutical formulations, aerosol delivery, etc. It can solve the problems of severe immune side effects and unfavorable vaccination, so as to prolong life and reduce heat source quality , the effect of high purity

Inactive Publication Date: 2011-02-09
崔栋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although a highly immunogenic viral protein mixture can be obtained, it is always in the form of injection, and the side effects of injection vaccination are relatively serious, which is not conducive to large-scale vaccination, especially for children, the elderly and the infirm. However, nasal spray vaccination has good tolerance , lower side effects, can be used for children, adults and the elderly, and is easy to use, can be vaccinated by oneself, and can be applied to a large number of people, which is the direction of improvement of influenza vaccine at present

Method used

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  • Atomizing grippe vaccine composition and preparation thereof
  • Atomizing grippe vaccine composition and preparation thereof
  • Atomizing grippe vaccine composition and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Influenza antigens are prepared according to the preparation method in this process, and can also be purchased from the market, and the influenza antigens are taken for preparation. Get sodium polystyrene sulfonate, sodium polystyrene sulfonate is the medicine approved by State Food and Drug Administration, is made into aqueous solution, makes its content be 0.5g / ml, gets influenza antigen and is made into aqueous solution, makes its content be 2.15mg / ml, mixed according to 8:1, stirred for 1 hour to make a mixed aqueous suspension. The suspension is sprayed into the human nasal cavity in an amount of 0.6 ml each time.

Embodiment 2

[0053] Apply the preparation method of this process to prepare influenza antigen, which can also be purchased from the market, get the prepared influenza antigen and mix it into 600ml, add interferon 10 4.5 Unit / L, 25ml of human serum albumin, and the rest are mixed with PBS phosphate buffer solution to make 1000ml spray influenza vaccine.

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Abstract

The invention relates to a preparation method of a spraying composition of influenza vaccine. The composition contains influenza virus antigens and drug-acceptable carriers which are chosen from interferon, ion exchange resins, human serum albumin or phosphate buffer.

Description

Technical field: [0001] The invention relates to a method for preparing a sprayed influenza vaccine composition, belonging to the field of biological pharmaceutical preparations. Background technique: [0002] Influenza, referred to as influenza (influenza), is mainly an acute respiratory infectious disease caused by type A (A) and type B (B) influenza viruses respectively. Influenza A virus often appears in a popular form and causes a worldwide influenza pandemic. Influenza B virus often causes local outbreaks of influenza and does not cause a worldwide influenza pandemic. At present, there is still a lack of effective drugs to treat influenza patients clinically. Influenza virus vaccine is the most effective means to prevent the occurrence and prevalence of influenza diseases. [0003] Influenza viruses belong to the family Orthomyxovindae and the genus Influenzavirus. Typical influenza virus particles are spherical, with a diameter of 80-120 nm. The influenza virus gen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/145A61K9/12A61K47/42A61K47/32A61P31/16
Inventor 崔栋
Owner 崔栋
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