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Calcium sulphate composite bone renovation material, preparation method and application thereof

A composite material, calcium sulfate technology, applied in the direction of bone implants, medical science, prosthesis, etc., can solve the problems of clinical application limitations, adverse effects of other system functions, etc., achieve good physical and chemical properties, simple preparation method, good The effect of applying the foreground

Inactive Publication Date: 2008-09-24
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Taking too much strontium by mouth can have adverse effects on the functions of other systems
[0014] The defects of traditional calcium sulfate bone repair materials have greatly limited its clinical application. The development of new bone repair materials with better properties and very safe research is needed in this field.

Method used

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  • Calcium sulphate composite bone renovation material, preparation method and application thereof
  • Calcium sulphate composite bone renovation material, preparation method and application thereof
  • Calcium sulphate composite bone renovation material, preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0030] Embodiment 1 The preparation of calcium sulfate composite material of the present invention

[0031] 1. Preparation of powder

[0032] Take α-calcium sulfate hemihydrate (α-CSH), strontium chloride (SrCl 2 ), were mixed according to the lower molar ratio shown in Table 1 (the same below), were ground and mixed evenly in a mortar, passed through a 400 mesh sieve, dried for later use, and all reagents used were of analytical grade.

[0033] The formula of various calcium sulfate composite materials of table 1

[0034]

[0035] 2. Preparation of solidification solution

[0036] Determine the liquid-solid ratio: The liquid-solid ratio will directly affect the setting time and the mechanical properties of the material. Therefore, before determining the coagulation time and compressive strength of strontium-doped calcium sulfate, the optimum liquid-solid ratio was determined first. The principle is: the minimum liquid-solid ratio when the powder material is completely ...

Embodiment 2

[0058] Example 2 In vivo histocompatibility experiment of calcium sulfate composite material of the present invention

[0059] The histocompatibility of biomaterials is an important issue to be considered first in the research of biomedical materials. Histocompatibility refers to the performance of biomaterials that are accepted by human tissues after a series of interactions occur at the material-tissue interface after they are in contact with human tissues. Intramuscular implantation experiment to observe the histological changes caused by materials implanted in vivo is the main system for evaluating histocompatibility at present. Intracellular enzymes control the life activities of cells. When stimulated by external factors, the changes of corresponding enzyme activities are earlier and more sensitive than the changes of cell morphology. Previous examples have proved that strontium-doped calcium sulfate with a strontium-doped amount of 0.5% has the best in vitro physical, ...

Embodiment 4

[0091] Embodiment 4 Using the calcium sulfate composite material of the present invention to repair bone defects

[0092] Clinically, trauma, infection, tumor and many other injuries can lead to bone structural defects. When the bone defect range exceeds the limit of bone self-repair ability or the bone tissue function is lost due to lesions, it is necessary to go through surgical methods and rely on Biomaterials are used to repair bone defects or replace diseased tissues, that is, to use bone grafts to fill defects and eliminate dead space, so as to restore the morphology, mechanical strength and anatomical function of the lesion. In order to further verify whether the strontium-doped calcium sulfate composite material of the present invention can be used as a good bone repair biomaterial, the present embodiment will use the strontium-doped calcium sulfate composite material as a bone repair material to carry out segmental bone defect of rabbit radius and rabbit femur Condyle...

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Abstract

The invention belongs to the tissue engineering field, in particular relates to a calcium sulfate composite material and a preparation method and purpose thereof, aiming at providing a calcium sulfate composite material which can be used as bone substitute material. The calcium sulfate composite material is mainly composed of calcium sulfate and a strontium-containing compound, wherein, the mol weight of the strontium accounts for 0.01-0.5 percent of the total mol weight of calcium and strontium. The calcium sulfate composite material creatively compounds the strontium-containing compound into the medical calcium sulfate so as to increase the activity of the material, causes the material to be able to slowly release the osteogenesis promoting element strontium partially during repairing process at the bone defect site. In addition, experiences prove that the calcium sulfate composite material of the invention has fine physical and chemical properties and biocompatibility, can be attached by osteogenesis cells well, and can well repair the bond defect, and is an excellent bone substitute material. The preparation method of the invention is simple and reliable, and has bright application prospect.

Description

technical field [0001] The invention belongs to the field of tissue engineering, and in particular relates to a calcium sulfate composite bone repair material and its preparation method and application. Background technique [0002] Bone tissue injury is a common clinical frequently-occurring disease, such as fractures caused by external forces, bone lesions and so on. Some of these lesions lead to a large area of ​​bone defect, which exceeds the limit of bone self-repair ability, or the loss of bone tissue function due to lesions. At this time, surgery is required to repair and replace the defect or diseased tissue with the help of biomaterials. [1] . [0003] At present, the transplantation methods mainly include autologous bone transplantation and allogeneic bone transplantation. Autologous bone transplantation has no immune rejection, and the cells and biologically active molecules in the transplanted bone can continue to survive at the recipient site and perform corre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/04A61F2/28
Inventor 裴福兴黄强李程周宗科张晖杨静沈彬
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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