Mono-methylation method for amines compounds
An amine compound and monomethyl technology is applied in the field of monomethylation of amine compounds to achieve the effects of simple process route, high reaction conversion rate and easy separation
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Embodiment 1
[0020] Embodiment 1 is synthesized N-methylaniline by aniline
[0021] 93g of aniline, 90g of DMC, and 37g of diethylenetriamine were put into the autoclave, and after nitrogen replacement, the temperature was raised to 100°C, and the reaction was carried out for 12 hours. Then the low boiling point substances were distilled off, and the fraction at 194-196°C was collected to obtain 99g of N-methylaniline with a yield of 92.5%.
Embodiment 2
[0022] Embodiment 2 is synthesized N-methylformanilide by N-formanilide
[0023] Put 121 g of N-formanilide, 108 g of DMC, and 4.6 g of potassium carbonate into the reaction flask, raise the temperature to 90° C., and react under reflux for 6 hours. Then the low boiling point substances were distilled off, the product was distilled under reduced pressure, and the fraction at 130-133° C. / 2.1 kPa was collected to obtain 130 g of N-methylformanilide with a yield of 96.3%.
Embodiment 3
[0024] Embodiment 3 synthesizes N-methyl octadecylamine by octadecylamine
[0025] Put 269g of octadecylamine and 270g of DMC, 162g of methanol, and 3.5g of NaY molecular sieve into the autoclave, raise the temperature to 100°C, and react for 3 hours under the condition of natural pressure increase. Then the product was filtered and distilled to remove low boiling point substances, cooled and dried to obtain 269g of N-methylaniline with a yield of 95%.
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