Multi-layered antiadhesion barrier

Abstract

The present invention relates to a multi-layered anti-adhesion barrier, particularly to a multi-layered anti-adhesion barrier comprising a nanofibrous structured base layer electrospun from a hydrophobic, biodegradable, biocompatible polymer and a polymer layer formed by coating a hydrophilic, biooriginated polymer on the base layer, and a method for the preparing the same. The multi-layered anti-adhesion barrier of the present invention can solve the problems of the conventional gel, solution, sponge, film or nonwoven type anti-adhesion systems, including adhesion to tissues or organs, flexibility, physical strength, ease of handling (ease of folding and bending), etc., offers improved user convenience. With a nanofibrous structure, the multi-layered anti-adhesion barrier of the present invention effectively blocks the infiltration or migration of blood and cells and promotes the healing of wounds. It is not torn or broken when folded or rolled and can be easily handled using small surgical instruments. Thus, it can minimize a foreign body reaction when used in various surgical operations.

Description

technical field [0001] [01] The present invention relates to a multilayer release film, and more particularly, to a multilayer release film having improved release properties and a method of making the same , solutions, sponges, films or non-woven anti-adhesive systems, including tissue or organ adhesion, elasticity, physical strength, ease of handling (easy to fold and bend), etc., thereby providing improved user convenience. By using the nanofibrous structure, the multi-layer anti-mucosal film of the present invention can effectively prevent the penetration or migration of blood and cells, and promote the healing of wounds. It will not tear or break when folded or rolled, and can be easily handled with small surgical instruments. Thus, it minimizes foreign body reactions when used in various surgical procedures. Background technique [0002] [02] Adhesion refers to the adhesion of adjacent organs or tissues due to blood outflow and coagulation due to inflammation, cuts, ...

AI Technical Summary

Problems solved by technology

However, since hydrophilic or weakly hydrophilic polymers lose their mechanical strength when swollen by water, the fibers may deform or tear during handling

[0021] [21] The problem with the above-mentioned technology using biodegradable synthetic polymers is that, since it is a biologically produced substance, inflammation cannot be avoided when the polymer comes into direct contact with tissue or blood

Despite the excellent elasticity of nanofibers, non-hydrophilic substances do not adhere well to wet tissue and thus cannot be easily fixed in place

[0022] [22] In summary, the problem with conventional techniques is that, since synthetic polymers are used, although these synthetic polymers are biodegradable, since they are biologically produced substances, when the polymer comes into direct contact with tissue or blood, will not avoid inflammation

In addition, despite the excellent elasticity of nanofibers, non-hydrophilic substances do not adhere well to wet tissues and thus cannot be easily fixed in place

Furthermore, the small diameter and porosity intended to improve drug and cell delivery or protect wounds is not suitable for anti-mucosal membranes for internal organs

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