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Skin osmosis promoting absorbing agent of cryptotanshinone

A technology of cryptotanshinone and absorbent, which is applied in the field of combined formulation of cryptotanshinone, a component of Salvia miltiorrhiza, and laurocaprolone, a transdermal factor, can solve the problems of irritation of the affected area, pain of patients, and inconvenience of treatment, and achieve the purpose of reducing irritation and reducing drug exposure. Dosage, the effect of reducing potential harm

Inactive Publication Date: 2008-09-03
TAISHAN MEDICAL UNIV
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

However, at present, cryptotanshinone is often used internally, and rarely reported as an external preparation, and usually, ethanol is used as a solvent, which can greatly stimulate the affected area, causing pain and inconvenience to the patient.

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  • Skin osmosis promoting absorbing agent of cryptotanshinone

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Embodiment Construction

[0025] The present invention can adopt following method to make:

[0026] Step 1. Take 100ml of dimethyl sulfoxide aqueous solution with a concentration of 65% and heat it to 45°C in a water bath for later use;

[0027] Step 2, take 2g of cryptotanshinone and dissolve it in the dimethyl sulfoxide solution prepared in step 1 under ultrasonic vibration (100W, 10S);

[0028] Step 3, take 5g of laurocaprazine under ultrasonic vibration (100W, 10S) and dissolve in the solution prepared in the second step;

[0029] Step 4, mixing the mixed solution prepared in the third step evenly under ultrasonic vibration (100W, 10S);

[0030] Step 5. Add the mixed solution prepared in the fourth step to 1000 ml by adding double-distilled water, and divide it into vials for storage.

[0031] The usage of preparation of the present invention:

[0032] 1. For mild-tempered domestic mammals, the affected area can be smeared directly after hair removal, until the affected area is completely covere...

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Abstract

The invention discloses a cryptotanshinone cutaneous penetration-enhancing absorbent aiming to realize the percutaneous absorption of cryptotanshinone through carrying by 1-dodecylazacycloheptan-2-one, which is used for treating body surface suppurative inflammation of mammals caused by staphylococcus aureus, pseudomonas aeruginosa and hemolytic streptococcus. The preparation method of the absorbent comprises the steps of dissolving 2g cryptotanshinone in 100ml 65% dimethyl sulfoxide aqueous solution heated to 45 DEG C under ultrasonic vibration; adding 5g 1-dodecylazacycloheptan-2-one into the obtained mixed solution under ultrasonic vibration, and mixing; and diluting to 2mg / ml with double distilled water (using cryptotanshinone as reference). The cryptotanshinone cutaneous penetration-enhancing absorbent has the advantages of quick action, good antiphlogistic effect, low irritation, and low side effects.

Description

technical field [0001] The invention relates to a combination formula of cryptotanshinone, a component of salvia miltiorrhiza, and laurocaprolone, a transdermal factor, which is suitable for suppurative inflammation on the body surface of mammals caused by Staphylococcus aureus, Pseudomonas aeruginosa and Streptococcus hemolyticus. Background technique [0002] Suppurative inflammation is an inflammation characterized by massive exudation of neutrophils accompanied by varying degrees of tissue necrosis and pus formation. It is very common in animals, but due to the habits of animals, it is difficult to implement the traditional oral administration and injection of antibiotics, and due to the abuse of antibiotics, drug-resistant strains are increasing day by day. Treatment brings a lot of trouble. [0003] There is no shortage of antibacterial Chinese herbal medicines in the treasure house of traditional Chinese medicine in the motherland. With the progress of the modernizat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/58A61K47/22A61P31/04
Inventor 巩念明
Owner TAISHAN MEDICAL UNIV
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