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Method for preparing inorganic bioactivity osseous tissue repair material with a plurality of shapes

A bioactive and repairing material technology, which is applied in the field of preparation of inorganic bioactive bone tissue repairing materials with various shapes, can solve problems such as displacement, difficulty in shaping, and easy migration of particles, and achieve good mechanical strength and large output , The effect that the process parameters are easy to control

Inactive Publication Date: 2008-08-13
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the brittleness of bulk ceramics, the particles are easy to move and shift, and it is difficult to shape, which limits its clinical application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1)Na 2 O-CaO-P 2 o 5 -SiO 2 Particle size selection of the inorganic amorphous biologically active powder of the constituent system: select the above-mentioned inorganic amorphous biologically active powder with a particle size of 50-1000 microns, add an appropriate amount of polyvinyl alcohol solution with a concentration of 1% as a binder, and mix evenly; Wherein the mass fractions of each component of the inorganic amorphous bioactive powder are as follows: CaO: 20, P 2 o 5 : 7, Na 2 O: 20, SiO 2 :41.

[0024] (2) Compression molding of powder: Weigh 0.10g of the above powder and pour it into a film tool (inner cavity size is φ5mm*20mm), press molding under a pressure of 20MP, and take it out after demoulding;

[0025] (3) Heat treatment: Put the prepared disc block into a zirconia or alumina sagger, heat treatment at 450°C for 3 hours in a temperature program controlled resistance furnace, and heat treatment at 800°C for 30 minutes, that is, the obtained dia...

Embodiment 2

[0027] (1) The particle size selection of the inorganic amorphous biologically active powder: select the inorganic amorphous biologically active powder with a particle size of 50 to 1000 microns, add an appropriate amount of polyvinyl alcohol solution with a concentration of 5% as a binding agent, and mix evenly. Wherein the mass fractions of each component of the inorganic amorphous bioactive powder are as follows: CaO: 28, P 2 o 5 : 6, Na 2 O: 28, SiO 2 :47. .

[0028] (2) Compression molding of powder: Weigh 0.16g of the above powder and pour it into a film tool (inner cavity size is φ5mm*20mm), press molding under a pressure of 25MP, and take it out after demoulding.

[0029] (3) Heat treatment: Put the prepared disc block into a zirconia sagger, and heat-treat it in a box-type resistance furnace controlled by temperature program at 450-850°C for 60 minutes, that is, a 5mm-diameter and 3mm-height Bioactive disk restorative material.

Embodiment 3

[0031] (1) Particle size selection of inorganic amorphous biologically active powder: choose inorganic amorphous biologically active powder (CaO-P 2 o 5 -Na 2 O-SiO 2 ) and the pore-forming agent in a mass ratio of 2:1, add an appropriate amount of polyvinyl alcohol solution with a concentration of 0.5% as a binder, and mix evenly, wherein the mass parts of each component of the inorganic amorphous bioactive powder As follows: CaO: 25, P 2 o 5 : 6, Na 2 O: 26, SiO 2 :48.

[0032] (2) Weigh 0.45g of the above-mentioned powder and pour it into a film tool (the inner cavity size is φ9mm*20mm), press and form it under a pressure of 50MP, and take it out after demoulding.

[0033] (3) Heat treatment: put the prepared cylindrical block into a zirconia sagger, and heat-treat it in a temperature-programmed box-type resistance furnace at 300-800°C for 300 minutes, that is, a biological body with a diameter of 9mm and a height of 4mm is obtained. Active porous cylindrical restor...

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PUM

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Abstract

The present invention discloses a method for preparing inorganic biological activity bone tissue repairing material with various shapes, including steps as follows: adhesive is added into 50-1000 micron inorganic amorphous biological activity powder, then mixed uniform with added pore former; thereinto, pore former quality accounts for 5-45% of mixture total quality; or adhesive is added into 50-1000 micron inorganic amorphous biological activity powder, and the obtained mixture is put on steel mould and is pressed forming; finally, is put in zirconia box, and is heat processed 1-5 hours in 300-900 degrees celsius, and can obtain inorganic biological activity bone tissue repairing material. The prepared bone tissue repairing material has various shape and has better mechanical strength, biocompatibility and certain biodegradable; the chemical constituent of material can regulated, and has simple preparing technology which the technological parameter is easy controlled and has large production.

Description

technical field [0001] The invention relates to bone tissue repairing, filling and tissue engineering repairing materials, in particular to a preparation method of inorganic bioactive bone tissue repairing materials with various shapes. Background technique [0002] Congenital aberrations, aging, trauma, tumors and other diseases, as well as surgical operations, will cause human hard tissue fracture, defect and necrosis, which will affect the limb function and normal life of the patient. At present, bone tissue repair and bone tissue engineering materials that have been clinically applied at home and abroad are not the same in composition, structure and strength. They still have great differences compared with natural bone, which leads to their biocompatibility and degradability. It is not ideal enough and directly affects the repairing effect of bone tissue. In the field of bone defect repair research, there is an urgent need for new biomaterials that match the mechanical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/02A61L27/58
Inventor 陈晓峰李向军赵娜如
Owner SOUTH CHINA UNIV OF TECH
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