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New medical purpose of privet and pharmaceutical formulation thereof

A technology of Ligustrum lucidum and medicine, which is applied in the field of new medicinal uses of Ligustrum lucidum and its pharmaceutical preparations, can solve problems such as the prevention and treatment of osteoporosis without a single medicine of Ligustrum lucidum, and achieve drug safety and preparation The process is simple and the curative effect is exact

Inactive Publication Date: 2008-08-13
普尔药物科技开发(深圳)有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Judging from the existing professional publications and patent documents, there is no new medicinal use of Ligustrum lucidum or its extracts for the prevention and treatment of osteoporosis, regulation of bone metabolism, and maintenance of bone health and its pharmaceutical preparations records

Method used

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  • New medical purpose of privet and pharmaceutical formulation thereof
  • New medical purpose of privet and pharmaceutical formulation thereof
  • New medical purpose of privet and pharmaceutical formulation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 Animal experiment

[0024] 1 Materials and methods

[0025] 1.1 Animals and materials

[0026] Animals: 120 11-month-old SPF-grade female SD rats (average body weight 389 g), purchased from Guangdong Medical Experimental Animal Center (animal qualification certificate number: SCXK (Guangdong) 2003-0002).

[0027] Medicinal materials: Ligustrum medicinal materials are collected from Yuyi, Jiangsu.

[0028] Feed: Low-calcium feed, medium-calcium feed, and high-calcium feed were all purchased from the United States (Harlan Teklad Inc., Madison, WI), and their nutritional composition is shown in Table 1:

[0029] Table 1 Rat Feed Nutrient Composition

[0030]

[0031] 1.2 Instruments

[0032] Bone densitometry instrument (pQCT, XCT2000, Germany Stratec Medizintechnik GmbH company)

[0033] Biomechanical measuring instrument (H10KM, British Hounsfield Experimental Equipment Company)

[0034] 2 Experimental methods

[0035] 2.1 Preparation of Ligustrum ...

Embodiment 2

[0128] Example 2 Cell experiment

Embodiment 2-1

[0129] Example 2-1 Routine cell culture

[0130] 1 material

[0131] UMR 106 cell ATCC(No CRL-1661)

[0132] DMEM medium (Cat.NO.12430-054) GIBCO company

[0133] Antibiotics (10X, containing penicillin, streptomycin) GIBCO Corporation

[0134] DMSO (Cat.NO.0231-500ml) American Amresco Company

[0135] PBS (Cat.No: 20012-027) GIBCO Corporation

[0136] 17β-Estradiol (Cat.NO: E-8875) Sigma

[0137] Fetal bovine serum (Cat.NO: 16000-044) American Life Technologies

[0138] Trypsin (Cat.NO: 15400-054) Canada Life Technologies

[0139] 2 main instruments

[0140] Cell Incubator (Model: 2323) US SHELDON Company

[0141] Ultra-clean workbench (Model: LAB / 04-EBC-2A) Singapore ESCO Company

[0142] Inverted Microscope (Model: 090-135-002) Leica Company, Germany

[0143] 3 methods

[0144] The cells were cultured in DMEM medium (containing 5% FBS+1×antibiotics), and the culture dish was placed in a constant temperature incubator (37°C, 5% CO2). When the confluence of adhere...

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PUM

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Abstract

The invention discloses a ligustrum lucidum and the new use for Chinese medicine of a ligustrum lucidum extractive for preparing medicines for prevention or treatment of osteoporosis, and also discloses a granule for prevention or treatment of osteoporosis, wherein, the granule comprises 25 to 35 percents of the ligustrum lucidum extractive and 65 to 75 percents of an excipient which chooses sucrose and dextrine, or is made into capsules. The capsules contain the ligustrum lucidum extractive. The ligustrum lucidum single-taste and the relative pharmaceutical preparation of the invention has the advantages of accurate curative effect, low side effects, more drug safety, simple preparation craft and lower cost in the application of prevention or treatment of osteoporosis.

Description

Technical field: [0001] The invention relates to medicines for regulating bone metabolism, maintaining bone health and preventing and treating osteoporosis, and in particular relates to the new medical application of Ligustrum lucidum and its extract and its pharmaceutical preparations. Background technique: [0002] Osteoporosis is a metabolic bone disease characterized by decreased bone mass, microarchitectural deterioration of bone tissue, and increased bone fragility and fracture risk. Osteoporosis is ranked alongside hypertension, arteriosclerosis, diabetes, and tumors by the international medical community, and is one of the five major diseases currently. At present, about 200 million people in the world suffer from osteoporosis, and there are nearly 90 million people with osteoporosis in my country, of which 20 million people have fractures. With the arrival of an aging society, its incidence rate is increasing year by year, which has brought serious consequences to ...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/16A61K9/20A61K9/48A61P19/10A61K131/00
Inventor 张岩黄文秀梁秉中车镇涛
Owner 普尔药物科技开发(深圳)有限公司
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