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Hemlock parsley oil self-emulsifiable oral medicine delivery system and preparing method thereof

A self-emulsification technology of Chuanxiong oil, which is applied in the field of medicine, can solve the problems that there is no public report on the self-emulsification technology of Chuanxiong oil, and achieve the effect of improving drug bioavailability, improving bioavailability, and simple preparation method

Active Publication Date: 2008-07-30
SICHUAN KELUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no public report on the self-emulsification technology of Chuanxiong oil

Method used

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  • Hemlock parsley oil self-emulsifiable oral medicine delivery system and preparing method thereof
  • Hemlock parsley oil self-emulsifiable oral medicine delivery system and preparing method thereof
  • Hemlock parsley oil self-emulsifiable oral medicine delivery system and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1 self-emulsifying Chuanxiong oil soft capsule

[0019] Put 20g of Chuanxiong oil, 72g of Tween 80 and 8g of ethanol into a plastic tank and mix evenly, then heat the mixture to 75°C, mix evenly, vacuumize, filter, keep warm, and press in a soft capsule making machine. Then put the soft capsule in the setting machine to finalize the shape. After washing, the soft capsules are dried at about 30°C for 12 hours.

Embodiment 2

[0021] Take 50g of Chuanxiong oil, 49g of Tween 60 and 1g of propylene glycol to prepare self-emulsified Chuanxiong oil soft capsules, and other steps are as described in Example 1.

Embodiment 3

[0023] Take 80g Chuanxiong oil, 4g Tween 80 and 16g isopropanol to prepare self-emulsified Chuanxiong oil soft capsules, and other steps are as described in Example 1.

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Abstract

The invention relates to an oral self-emulsifying drug delivery system of RhizomaChuanxiong oil; the system uses RhizomaChuanxiong oil as the oil phase, and solves the problem that the surface active agent dosage is too much owing to excessive volume of the oil phase. The system comprises RhizomaChuanxiong oil, co-emulsifier and surface active agent, which can effectively improve the bioavailability of RhizomaChuanxiong oil and medicine taking is very safe and convenient. The invention also provides the preparation method for RhizomaChuanxiong oil, including the following steps: mixing the RhizomaChuanxiong oil as the oil phase and the corresponding surface active agent and co-emulsifier according to a certain ratio to form medical solution, thus forming the RhizomaChuanxiong oil oral dilution medicine system. After being taken in, the medical solution is mixed with the water in the gastric juice and then together turn into emulsion under gastric motor, thus improving the bioavailability and treatment efficiency. The preparation method of the invention dilution medicine system is simple, and the medical solution can be made into soft capsule, hard capsule or other oral dosage forms; The invention has low cost, and reliable performance, which is convenient for storage and transportation.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a Chuanxiong oil self-emulsifying oral drug delivery system and a preparation method thereof. Background technique [0002] Chuanxiong is one of the most commonly used traditional Chinese medicines in clinical practice. It is often used to treat various blood disorders in clinic. A large number of studies have been conducted on the effect and mechanism of Rhizoma Chuanxiong in promoting blood circulation and removing blood stasis in China. It has been confirmed that Rhizoma Chuanxiong can improve brain and peripheral microcirculation, significantly increase cerebral blood flow, inhibit platelet activation, reduce red blood cell and platelet aggregation, and treat experimental cerebral ischemia. Histomorphology and brain function are protective. In recent years, studies have found that volatile oil from rhizome of ligusticum Chuanxiong, 1), especially the phthalide compounds in it, play a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/236A61K9/107A61K9/16A61K9/20A61K9/48A61P7/00A61K125/00
Inventor 蔡勤梁隆
Owner SICHUAN KELUN PHARMA CO LTD
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