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Quinine-containing controlled-release formulations

A technology for controlled-release preparations and preparations, which can be used in pill delivery, ICT adaptation, active ingredients of heterocyclic compounds, etc., and can solve problems such as QT prolongation will not be reached.

Inactive Publication Date: 2008-07-23
MUTUAL PHARMA CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although quinine is a diastereomer of quinidine, it does not cause QT prolongation to the extent that quinidine does, however, in patients with a history of arrhythmia or QT prolongation in potentially arrhythmic risk situations quinine should be used with caution

Method used

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  • Quinine-containing controlled-release formulations
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  • Quinine-containing controlled-release formulations

Examples

Experimental program
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Effect test

preparation example Construction

[0147] The preparation steps of the support layer components are: mixing, if possible, wetting with a binding solution in a known field, and then making the mixture into a dry granular shape. The mixture can be sieved and then mixed with other components to obtain an easy-flowing homogeneous mixture. The prepared support layer mixture is coated on the core and pressed into a surface layer. The support layer may be coated on one or two base surfaces of the core, or on the entire core surface except for one base surface, or on the entire side surface except for the two base surfaces. The support layer is usually about 1000-4000kg / cm 2 The pressure is overwhelming.

[0148] In one embodiment, the sustained-release preparation comprises (a) a deposit-core, which has a defined geometric shape, contains a therapeutically effective amount of quinine or a pharmaceutically acceptable salt thereof, and a core polymer material, the core polymer material is selected from (1) Expansive polymer...

Embodiment 1

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1200

[0194] The ingredients other than the lubricant are mixed in a high-shear granulator. Water is added, the wet mixture is granulated, the granules are sieved, dried and ground. Then add the granules into the low-shear mixer, add lubricant and stir. The final blend is compressed in a tablet press to form a sustained-release quinine dosage form.

Embodiment 2

[0195] The ingredients other than lubricant and flow agent are mixed in a low shear mixer for 20 minutes. Add lubricant and flow agent and stir for 5 minutes. Press directly in the tablet press.

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Abstract

Disclosed herein are controlled-release quinine formulations and methods of preparing the same. Also disclosed are uses for the manufacture of a medicament or preventing or treating malaria, leg cramps, or babesiosis by administering the controlled-release quinine formulations. The controlled-release quinine formulations may help to reduce or eliminate adverse side effects typically associated with the dosing of quinine.

Description

Technical field [0001] This application relates to a quinine controlled-release preparation and a preparation method thereof, and also relates to the application in the preparation of a medicine for treating or preventing malaria, leg cramps or Babesia. The treatment or prevention is achieved by applying the quinine controlled-release preparation of the present invention. The quinine controlled-release preparation can help reduce or eliminate the adverse side effects usually caused by the administration of quinine. Background technique [0001] Malaria is caused by Plasmodium falciparum (P.falciparum), Plasmodium vivax (P.vivax), Plasmodium ovale (P.ovale), and Plasmodium vivax (P.malariae), which belong to the species Plasmodium. A kind of parasitic disease. Malaria parasites can cause intermittent episodes of cold and heat, affecting most organs and systems such as red blood cells, kidneys, liver, spleen and brain. According to estimates by the World Health Organization (WHO), ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/49A61K9/20A61K9/16
CPCY02A50/30Y02A90/10
Inventor 杜洁R·罗伯茨K·阿纳多
Owner MUTUAL PHARMA CO INC
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