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Method for producing titanium dioxide coating capillary column with liquid deposition method

A titanium dioxide, liquid phase deposition technology, applied in the field of preparation of titanium dioxide coated capillary column, can solve the problems of poor repeatability, complicated preparation steps, and insufficient understanding of capillary separation and analysis applications, and achieve the effect of low cost and simple preparation process

Inactive Publication Date: 2008-07-16
WUHAN UNIV
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Problems solved by technology

As a stationary phase of liquid chromatography, it has been applied to a certain extent in normal phase chromatography, reversed phase chromatography and ion exchange chromatography, but its application in capillary separation analysis has not been fully understood, and there are only five related literature reports.
TiO2-coated capillary columns are usually prepared by the sol-gel method, but the preparation steps of this method are relatively complicated and the reproducibility is poor

Method used

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  • Method for producing titanium dioxide coating capillary column with liquid deposition method
  • Method for producing titanium dioxide coating capillary column with liquid deposition method

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Embodiment Construction

[0015] Preparation of titania-coated capillary columns:

[0016] (1) Activation of the capillary: the quartz capillary is washed with 1M sodium hydroxide for 2-4 hours, water for 0.5-1 hour, 1M hydrochloric acid for 4-8 hours, H 2 Rinse with O for 0.5-1 hour, then dry with nitrogen at 120-160°C for later use.

[0017] (2) Preparation of titanium dioxide-coated capillary column: Mix 0.2M ammonium fluotitanate and 0.6M boric acid in equal volumes, then inject into the activated capillary, seal both ends of the capillary with silicone rubber, and place in a constant temperature water bath at 35±1°C Deposit in medium for 16-24 hours, blow out the reaction solution, wash with water and dry with nitrogen at 120°C. Subsequently, the capillary was washed sequentially with 0.1 M NaOH and deionized water. Afterwards, the capillary with deposited titanium dioxide film was placed in a muffle furnace, the temperature was programmed to 300°C at a rate of 1°C / min, and kept at 300°C for 2 h...

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Abstract

The invention provides a method for preparing capillary column of titanium dioxide coating by using liquid phase deposition method; fluotitanic acid ammonium is taken as raw material and a film layer of the titanium dioxide is deposited on inner wall of the quartz capillary through the liquid phase deposition method. The novel method is used for preparing the capillary column of the titanium dioxide coating. The invention is simple in method, and the prepared capillary column of the titanium dioxide coating can be successfully used in separation and pre-enrichment of biological samples; the invention can also used for preparing the capillary column of other inorganic oxide coating.

Description

technical field [0001] The invention relates to a method for preparing a capillary column coated with titanium dioxide by a liquid phase deposition method. Background technique [0002] The miniaturization and automation of analytical instruments is the main trend in the development of chemical and biological analysis. The miniaturization of chromatographic technology has become one of the key technologies to establish an environment-friendly analysis system because it can greatly reduce the consumption of reagents and samples. The miniaturization of the chromatographic process can be realized by replacing the commonly used chromatographic column with capillary. According to the existence form of the stationary phase in the capillary, it can be divided into capillary coated column, capillary packed column and capillary monolithic column. The preparation of capillary coated columns is simple and convenient, and has been widely used in the separation and analysis of various c...

Claims

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Application Information

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IPC IPC(8): C03C17/25
Inventor 冯钰锜林博李烃
Owner WUHAN UNIV
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