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Agent for external application to the skin

A skin external preparation, Polygonum indigo technology, applied in the field of skin external preparations, can solve unsatisfactory, precipitation, coloring and other problems

Inactive Publication Date: 2008-07-02
HAYASHIBARA BIOCHEMICAL LAB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, when these components are blended in external skin preparations, there are problems such as poor stability and solubility, especially plant extracts, etc., which cause precipitation, odor, coloring, etc. rash and other safety issues, unsatisfactory

Method used

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  • Agent for external application to the skin
  • Agent for external application to the skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0174]

[0175] The whole plant of raw Polygonum indigo was chopped, 23 parts by mass of purified water was added to 15 parts by mass of it, stirred at room temperature for 10 minutes for extraction, centrifuged to obtain a supernatant, and the supernatant was autoclaved. The solution was put into the centrifuge again, and the supernatant was filtered to obtain the Polygonum indigo extract. Because this product has various physiological activities such as melanin production inhibition, elastase activity inhibition, lipase activity inhibition, sebum secretion regulation from subcutaneous fat glands, SOD-like effect, DPPH free radical capture effect, anti-aging effect, etc., it can be effective It is used as an active ingredient of skin external preparations for whitening and / or skin beautification.

[0176] The appearance and properties, pH, coloring degree (OD420nm) and turbidity (OD720nm) when the Polygonum indigo extract was prepared when diluted twice with purified water,...

Embodiment 2

[0181]

[0182] The whole plant of raw Polygonum indigo was chopped, 3 parts by mass of equal mass mixed with purified water and ethanol were added to 4 parts by mass, and after stirring for 20 minutes for extraction, centrifugation was performed to obtain a supernatant, and the supernatant was subjected to Autoclave to obtain Polygonum indigo extract. The present invention is Polygonum indigo extract capable of suppressing precipitation, browning, and odor, because it has melanin production inhibition, elastase activity inhibition, lipase activity inhibition, regulation of sebum secretion from subcutaneous fat glands, SOD-like action, DPPH It has various physiological activities such as free radical scavenging action and anti-aging action, so it can be effectively used as an active ingredient of skin external preparations for whitening and / or skin beautification or oral use.

Embodiment 3

[0184]

[0185] The Polygonum indigo extract (without 1,3-BG) prepared by the method in Example 1 was filtered with an ultrafiltration membrane to prepare the Polygonum indigo extract. Even if this product is stored for a long period of time, there is little precipitation and turbidity. In addition, fine particles are removed by ultrafiltration, so the permeability to a membrane with a pore size of 0.45 μm is compared with that of a standard product that does not use an ultrafiltration membrane. , exceptionally (more than 100 times) increased, so it can be sterilized with a membrane, and it is an easy-to-handle Polygonum indigo extract. This product is Polygonum indigo extract that inhibits the occurrence of browning and odor. It has inhibitory effects on melanin production, elastase activity, lipase activity, regulation of sebum secretion from subcutaneous fat glands, SOD-like effects, and DPPH free radicals. It has various physiological activities such as capturing effect ...

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Abstract

The object of the present invention is to provide a melanin production inhibitor and / or an elastase activity inhibitor containing a plant extract that is highly safe and has no problems in terms of stability, odor, and precipitation as an active ingredient, and a combination of these substances. An external preparation for skin having an excellent whitening effect or skin beautifying effect solves the above-mentioned problems by providing an external preparation for skin containing an extract of Polygonum indigo.

Description

technical field [0001] The present invention relates to an extract of Polygonum indigo and an external preparation for skin containing the extract of Polygonum indigo as an active ingredient. In particular, the present invention relates to a melanin production inhibitor and / or an elastase activity inhibitor and an agent for whitening and / or containing them as an active ingredient. An external skin preparation for skin beautification, wherein the melanin production inhibitor and / or elastase activity inhibitor contains an extract extracted from Polygonum indigo with an aqueous solvent. Background technique [0002] Wrinkles, fine lines or brown spots, freckles, and skin pigmentation after sun exposure have become one of the most serious skin troubles for middle-aged and elderly people and women. Therefore, various skin-beautifying and whitening ingredients have been proposed. As such active ingredients for skin beautification or whitening, for example, kojic acid or its deriv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61Q19/02A61Q19/08A61K8/67A61K8/60A61K36/70A61P1/02A61P17/04A61P17/10A61P17/16A61P31/10A61P39/06A61P43/00
CPCA61K8/602A61K8/676A61K8/35A61K8/347A61K2800/75A61K2800/782A61K36/704A61Q19/008A61K8/97A61Q19/08A61Q19/02A61K8/368A61K8/9789A61P1/02A61P17/00A61P17/04A61P17/10A61P17/16A61P17/18A61P31/10A61P39/06A61P43/00A61K8/498
Inventor 京野文代末本保雄高山悟竹内诚人
Owner HAYASHIBARA BIOCHEMICAL LAB INC
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