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Medical blood-stopping healing agent for wound-surface and using thereof

A kind of wound surface, a part of the technology, applied in the field of medical wound hemostatic and wound healing agents, to achieve good biocompatibility

Active Publication Date: 2008-07-02
青岛博益特生物材料股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Natural biopolysaccharides have good biocompatibility, can be biodegraded and absorbed in the body, and do not produce immune reactions. Therefore, using natural biopolysaccharides as raw materials for wound hemostasis and healing agents is the first choice, but no such reports have been seen so far

Method used

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Embodiment Construction

[0009] The hemostatic and healing agent for medical wound surface of the invention is composed of two aqueous solutions, one is an aqueous solution of oxidized polysaccharide containing dialdehyde groups, and the other is an aqueous solution of water-soluble chitosan.

[0010] 1. Preparation of oxidized polysaccharides containing dialdehyde groups

[0011] 1. Preparation of oxidized carboxymethyl cellulose containing dialdehyde groups: Weigh 2.2 g of carboxymethyl cellulose powder, add it to a 250 ml glass conical flask, add 97.8 g of water, stir and dissolve on an electric stirrer to obtain carboxymethyl cellulose Cellulose aqueous solution. This aqueous solution adjusts the pH value to pH5.0 with 5% (weight percent, the same below) acetic acid solution, adds oxidizing agent NaIO 4 0.25 g of solid, sealed, wrapped in black paper to avoid light, and stirred for oxidation reaction at room temperature for 30 h. After the reaction is completed, add 4 times the volume of 95% eth...

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Abstract

The invention relates to a medical wound surface hemostatic and wound healing agent, which is characterized in that the invention consists of two parts of water solution, one part is the oxidative polysaccharide water solution containing dialdehyde, and the other part is the water-soluable chitosan water solution. The medical wound surface hemostatic and wound healing agent can be applied in the preparation of drugs or medical devices for wound surface sealing and wound surface hemostasis, and the invention can also be applied in the preparation of drugs or medical devices for the promotion of wound surface healing and the prevention of postoperative tissue adhesion. The medical wound surface hemostatic and wound healing agent of the invention has significant effects on wound surface sealing, hemostasis, promotion of wound surface healing, prevention of postoperative tissue adhesion and other aspects, at the same time, the biocompatibility is good, which can not cause the tissue immune response, and the polysaccharides can not generate side effects on organisms after the in vivo degradation, so the safety is good.

Description

technical field [0001] The invention relates to a medical product, in particular to a medical wound hemostatic healer and its application. Background technique [0002] Medical wound hemostatic and healing agents have many uses in the medical field, including sealing and hemostasis of human and animal surgical wounds, sealing and repairing of physiologically active tissue wounds, and adhesion between physiologically active tissues. Fibrin glue is a medical wound hemostatic agent, which is a protein biological product extracted from human and animal plasma. It is mainly used in surgical wounds to stop bleeding, promote wound healing, and seal defect tissues. It has been widely used in China, Europe, America, Japan and other countries The country's surgical field has been widely used, and its curative effect has been affirmed. However, fibrin glue made from allogeneic human or animal serum may stimulate immune side effects, and there is a danger of infecting patients with blo...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L31/06A61K31/722A61K31/717A61P7/04
Inventor 刘万顺韩宝芹顾其胜
Owner 青岛博益特生物材料股份有限公司
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