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Inhalator capsules

A technology of cartridges and inhalation methods, applied in the direction of antibacterial drugs, capsule delivery, etc., which can solve problems such as difficulties, inability to provide therapeutic effects, and incomplete mechanical and physiochemical properties

Inactive Publication Date: 2008-06-18
柏林格英格尔海姆药物有限及两合公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

They are also sticky under humid conditions, thus being disadvantageous for efficient filling of cartridges and / or use, for example, in inhalers
In particular, it can be difficult to create a sufficiently large or stable opening in the cartridge to release the powder
Part of the powder sticks to the wall of the cartridge and does not provide therapeutic benefits as inhaled
In conclusion, the mechanical and physiochemical properties of the known products of the prior art, including those applying the aforementioned plastic materials, are not entirely satisfactory

Method used

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Examples

Experimental program
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Effect test

Embodiment approach

[0025] Said cartridge according to the invention contains a sorbent-polymer composition, ie at least a part of the cartridge is prepared from such a substance. According to a preferred embodiment of the invention, the cartridge consists entirely or essentially of a sorbent-polymer composition, ie a sorbent-polymer composition comprising at least one sorbent.

[0026] The expression sorbent is used in this specification to describe a component that is capable of reacting or interacting with an undesired chemical component in the cartridge (i.e., in the vicinity of the drug composition) that contributes to the The adsorbent has affinity and can be retained by the adsorbent as much as possible. Although based on different reaction mechanisms, the expressions "adsorbent" and "absorbent" are used in the same meaning and interchangeably in this specification.

[0027] Any material capable of absorbing moisture or otherwise absorbing moisture from the surrounding atmosphere, or each...

Embodiment

[0083] Cartridges of size 3 were prepared as follows:

[0084]The sorbent-polymer composition comprised 6-7% by weight of high-density polyethylene (HDPE), 3% by weight of EVA (elastomer) and 30% by weight of synthetic zeolite (molecular sieve 4A, maximum particle size 20 μm). Premixes were first made manually from HDPE and EVA. This step involves mixing the synthetic zeolite in a twin-screw compounding extruder. The mixture is converted into granular form. The granules can, as long as they are not processed further immediately, be stored in aluminum bags welded to exclude moisture. The granules were processed by means of injection molding into cartridges of size 3 with an MFI (melt flow index) setting of about 18 and an injection channel of 0.6 mm used. According to the second variant the sorbent-polymer composition comprises 66% by weight of high-density polyethylene (HDPE), 3% by weight of EVA (elastomer), 30% by weight of synthetic zeolite (molecular sieve 4A, maximum p...

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Abstract

The invention relates to a capsule, which is used, in particular, in the form of a package for inhalation formulations and comprises at least one cavity encased by a wall. Said invention is characterised in that at least one part of the wall comprises a polymer composition containing at least one type of absorber. The preferred use thereof, an inhalator and a secondary packing means containing said capsule are also disclosed.

Description

technical field [0001] The invention relates to cartridges for use as primary packaging, in particular for pharmaceutical inhalation formulations. The cartridge according to the invention is an integral part of a usable powder inhaler. Background technique [0002] Aerosol therapy in medical settings for lung inhalation plays an important role in the treatment of many lung diseases. In addition to nebulizing active substance-containing liquids, there are also in particular powder inhalers for the use of active substance formulations in powder form. [0003] Single-dose and multi-dose devices are known in the field of powder inhalers. In single-dose powder inhalers the dosing can mostly take place in the form of cylindrical cartridges containing the powder formulation. Powder formulations comprise the active substance and generally one or more auxiliaries in micronized form (with a particle size of about 1 to 5 μm). If a cartridge is used as the container, it is opened in...

Claims

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Application Information

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IPC IPC(8): A61K9/48
CPCA61K9/4808A61K9/4816A61P31/06A61K9/48
Inventor D·兰斯瑟尔D·赫驰莱尼尔J·施维B·兹伦比尔格
Owner 柏林格英格尔海姆药物有限及两合公司
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