Medicament elution instrument nanometer class colon washer machineole drug releasing structure and preparing method thereof

Abstract

The invention relates to a nanometer pore-space medicine-relieving structure for medical elution of the instrument and the preparation method. By adopting acid-solution-corrosion bore-forming or the method of anodization, or acid-solution-corrosion bore-forming first, anodization second, or the method combining micro-arc oxidation and micro-arc nitridation, single-sized, double-sized or multi-sized nanometer pore can be prepared directly in the raw material of the instrument body, that is, a plurality of nanometer bores distributed in an even size, or distributed in two or more uneven sizes including the statistical average of the bore diameter and the bore depth are prepared. The invention includes the following technical steps (1) pre-process the surface of an instrument body; (2) prepare pores; (3) post-process of the surface of the instrument; (4) prepare the medicine; (5) spray the medicine. The invention can reduce the risk of thrombosis caused by planting the instrument which uses polymer carrier for carrying medicine into the tissue of human body and control effectively the medicine-releasing speed, so that the post-operation restenosis rate can be reduced obviously. The invention is of simple technique, short production period and low production cost.

Description

technical field [0001] The invention relates to a drug release structure with nanoscale holes for a drug eluting device and a preparation method thereof. Background technique [0002] Drug-eluting devices include vascular stents, catheters, guide wires, cardiac pacemakers, heart valves, surgical implant materials, hard tissue implants, and other medical devices that need to release drugs. The metal mesh device of the pipeline, the materials constituting the bracket include stainless steel, titanium alloy, cobalt alloy and nickel-titanium memory alloy. Vascular stents are the main means of interventional therapy for cardiovascular and peripheral vascular occlusive lesions. The cavity remains open. Vascular stents can be divided into bare stents, drug-eluting stents, polymer-coated stents, metal-coated stents, radioactive stents and artificial blood vessel-covered stents according to the surface state. The first stents used are basically bare stents. Since the stent is a he...

AI Technical Summary

Problems solved by technology

This kind of drug stent containing polymer coating can reduce the incidence of restenosis to less than 10% in clinical application, but after the drug stent is implanted in the human body, the concentration of the polymer increases correspondingly due to the continuous decrease of the drug , may lead to the formation of thrombus; and the preparation process is complicated, the production cycle is long, and the production cost is high

[0004] refer to figure 2 As shown, in order to solve the above problems, domestic and foreign drug-loading systems usually obtain holes or other forms of drug storage mechanisms on the body of drug-eluting devices by laser, and then store drugs in these holes or drug storage mechanisms. These holes are the smallest. The size is also micron-level or even visible to the naked eye; in the figure, holes 50 for storing anti-restenosis drugs 40 are evenly embedded in the instrument body 10, and the smallest size of these holes 50 is micron-level, even visible to the naked eye; Although this micron-sized or even larger-sized hole 50 is very beneficial for storing large doses of drugs 40, it brings about the reduction of physical properties such as rapid release of drugs and body support.

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