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Medicament release structure carrying apertured and polyalcohol as well as its preparing method

A polymer and hole technology, applied in medical science, prosthesis, surgery, etc., can solve the problem of fast drug release, etc., and achieve the effect of reducing restenosis rate, reducing polymer content, and good blood vessel restenosis

Active Publication Date: 2008-04-16
LEPU MEDICAL TECH (BEIJING) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The object of the present invention is to provide a drug release structure that uses a mixture of active drugs and a small amount of polymers in different types of holes as the active drug carrier , to solve the problem of thrombus formation caused by the existing drug-eluting devices that completely use polymer carriers to carry drugs after implantation in human tissues, and the problem of excessive drug release caused by the absence of polymers, which can more effectively control the release of drugs, Safer to use, better therapeutic effect

Method used

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  • Medicament release structure carrying apertured and polyalcohol as well as its preparing method
  • Medicament release structure carrying apertured and polyalcohol as well as its preparing method
  • Medicament release structure carrying apertured and polyalcohol as well as its preparing method

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Embodiment Construction

[0049] Below in conjunction with accompanying drawing and preferred embodiment the present invention is described in further detail:

[0050] Referring to Fig. 3, a drug release structure used for drug-eluting devices co-loaded with holes and polymers mainly includes a device body 10, a film layer 40, holes 50, a mixture 80, etc.; the device body 10 is selected from biophase The medical material with good capacity is provided with holes on the device body 10, and the large number of holes are single-size or double-size or multi-size nanoscale holes 50, that is, a uniform size distribution or including pore diameter or hole depth. The statistical average of two or more n nanoscale pores 50 with non-uniform size distribution. The so-called nanoscale pores are not nanoscale pores less than 100nm in the absolute sense. Nanoscale pores less than 1μm and greater than 1nm are called nanoscale pores, specifically referring to the pore size Nano-scale pores (pores) with a depth of less...

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Abstract

The present invention relates to a hole for the medicine elution apparatus and a polymer carrying medicine releasing structure and the preparing method thereof. The invention includes an apparatus body which is arranged with large numbers of holes, the large number of holes are nano-scale holes with single dimension or double dimensions of a plurality of dimensions, namely n nano-scale holes with equal dimension arrangement or two or more asymmetrical dimension arrangement with the statistical average value including the pore diameter of pore depth, the holes are structure of medicine-carrying groove or pore, and the apparatus body includes or not includes an outermost membrane layer, the mixture of medicine and polymer exists in the hole and the mixture adheres to the surface of the apparatus body; the carrier carrying the medicine is no longer the simple hole or polymer, the holes and a few polymers commonly supports the active medicine and does controlled-releasing to the medicine, facilitates that the medicine has a strong adsorbability and a good controlled-releasing effect, as the content of the polymer is small the invention has the advantages of reducing the risk formed by the long-period thrombus and safer using and better treating effect.

Description

technical field [0001] The invention belongs to the field of drug-eluting devices, and relates to a drug-releasing structure co-loaded by holes and polymers used in drug-eluting devices and a preparation method thereof. Background technique [0002] Drug-eluting devices include vascular stents, catheters, guide wires, cardiac pacemakers, heart valves, surgical implant materials, hard tissue implants, and other medical devices that need to release drugs. The metal mesh device of the pipeline, the materials constituting the bracket include stainless steel, titanium alloy, cobalt alloy and nickel-titanium memory alloy. Vascular stents are the main means of interventional therapy for cardiovascular and peripheral vascular occlusive lesions. The cavity remains open. Vascular stents can be divided into bare stents, drug-eluting stents, polymer-coated stents, metal-coated stents, radioactive stents and artificial blood vessel-covered stents according to the surface state. The fir...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16A61L27/56A61L27/54
Inventor 张昱昕吕树铮
Owner LEPU MEDICAL TECH (BEIJING) CO LTD
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