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Medicament compound for treating cardiovascular disease and preparing method thereof

A composition and cardiovascular technology are applied in the field of medicinal compositions of astragalus saponins and ginseng stem and leaf saponins extracts for the treatment of cardiovascular diseases, which can solve the problems such as reports of no drug composition being found, and achieve significant myocardial ischemia, anti-inflammatory and anti-inflammatory effects. Effects of myocardial ischemia

Inactive Publication Date: 2008-06-18
BEIJING ROCK PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the data retrieval, no report was found on the pharmaceutical composition composed of ginseng stem and leaf saponin extract and astragaloside

Method used

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  • Medicament compound for treating cardiovascular disease and preparing method thereof
  • Medicament compound for treating cardiovascular disease and preparing method thereof
  • Medicament compound for treating cardiovascular disease and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049]100kg of ginseng stems and leaves were extracted by heating and refluxing with 10% ethanol, the extracts were filtered and combined, concentrated under reduced pressure, the concentrated solution was added with ethanol to make the alcohol content 50%, left to cool and then filtered, the precipitate was discarded, and the filtrate was concentrated under reduced pressure to no alcohol taste, added appropriate amount of deionized water, extracted 3 times with n-butanol, recovered the n-butanol layer, concentrated and dried to obtain total saponins of ginseng stems and leaves. The total saponins of ginseng stems and leaves were dissolved in 10L deionized water, passed through the AB-8 macroporous resin column according to the ratio of adsorption amount 5:1 (resin amount and sample amount), and left to stand for 90min. The column volume was eluted with deionized pure water, discarded the eluent, and then eluted with 5 times the column volume of 20% ethanol solution, collected ...

Embodiment 2

[0053] 100kg of ginseng stems and leaves were extracted by heating and refluxing with 15% ethanol, the extracts were filtered and combined, concentrated under reduced pressure, the concentrated solution was added with ethanol to make the alcohol content 60%, left to cool and then filtered, the precipitate was discarded, and the filtrate was concentrated under reduced pressure to no alcohol taste, added appropriate amount of deionized water, extracted 3 times with n-butanol, recovered the n-butanol layer, concentrated and dried to obtain total saponins of ginseng stems and leaves. The total saponins of ginseng stems and leaves were dissolved in 10L deionized water, passed through the AB-8 macroporous resin column according to the ratio of adsorption capacity 10:1 (resin volume and sample volume), and left to stand for 90min. The column volume of deionized water was eluted, the eluent was discarded, and then eluted with 30% ethanol solution of 6 times the column volume, and the 3...

Embodiment 3

[0057] 100kg of ginseng stems and leaves were extracted by heating and refluxing with 20% ethanol, the extracts were filtered and combined, concentrated under reduced pressure, the concentrated solution was added with ethanol to make the alcohol content 70%, left to cool and then filtered, the precipitate was discarded, and the filtrate was concentrated under reduced pressure to no alcohol taste, added appropriate amount of deionized water, extracted 3 times with n-butanol, recovered the n-butanol layer, concentrated and dried to obtain total saponins of ginseng stems and leaves. The total saponins of ginseng stems and leaves were dissolved in 10mL of deionized water, passed through the AB-8 macroporous resin column according to the ratio of adsorption amount 20:1 (resin amount and sample amount), and stood for 90min. The column volume of deionized pure water was eluted, the eluent was discarded, and then 7 times of the column volume was eluted with 35% ethanol solution, and th...

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Abstract

The invention discloses a drug combination for the treatment of cardiovascular diseases and a preparation method; the active components of the drug combination are extract of ginseng stems and leaves saponin and radix astragali saponin; the drug combination is mainly used in the treatment of coronary heart disease, simultaneously also has a therapeutic effect to the angina caused by lack of myocardial Blood, myocardial infarction, arrhythmias, heart failure and other cardiovascular diseases.

Description

Technical field: [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a ginseng stem and leaf saponin extract (containing Rg 1 and Re20% or more), the pharmaceutical composition of astragaloside and the preparation method of the composition. Background technique: [0002] Ginsenosides from stems and leaves of ginseng are extracted and processed from ginseng stems and leaves, which have similar chemical components and pharmacological activities to ginsenosides extracted from ginseng roots, but the cost of extraction and processing is greatly reduced, saving rare plant resources and reducing From the perspective of cost, it is an ideal substitute for ginsenoside. [0003] A large number of studies have shown that ginsenoside is a typical natural medicine that strengthens the body and strengthens the body. It has immune regulation, invigorates the spleen and replenishes qi, and is suitable for palpitations, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K31/7048A61K9/08A61K9/14A61K9/16A61K9/20A61K9/48A61P35/00A61P9/10A61P9/06A61P9/04B01D15/08A61K31/704
Inventor 曲守伟侯海燕王海勇
Owner BEIJING ROCK PHARMA
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