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Coagulation and fibrinolytic cascades modulator

A technology for promoting coagulation and prothrombin, which can be used in coagulation/fibrinolytic factors, blood diseases, and the determination/examination of microorganisms, which can solve problems such as less research.

Inactive Publication Date: 2008-05-21
THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

polyP is found in the natural environment and has been found in bacterial, fungal, animal and plant cells, but its presence in human cells remains poorly studied[1]

Method used

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  • Coagulation and fibrinolytic cascades modulator
  • Coagulation and fibrinolytic cascades modulator
  • Coagulation and fibrinolytic cascades modulator

Examples

Experimental program
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Effect test

Embodiment

[0101] polyP affects the rate of plasma coagulation and the rate of fibrinolysis

[0102] The role of polyP in blood coagulation and fibrinolysis was initially investigated using a combined model of plasma coagulation and fibrinolysis. In this system, coagulation of citrated, collected normal human plasma was initiated by the addition of calcium chloride. Coagulation initiated in this way occurs via the intrinsic pathway of blood coagulation and is relatively slow without the addition of contact activators. Thrombin (the last enzyme in the coagulation cascade) proteolytically converts fibrinogen to fibrin, which spontaneously polymerizes to form a fibrin gel or clot. Coagulation of fibrin is associated with an increase in plasma turbidity, which can be easily monitored by measuring changes in absorbance at 405 nm. Addition of calcium ions concurrently with the addition of plasminogen activator to plasma results in activation of plasminogen to plasmin and subsequent lysis of ...

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Abstract

The invention provides a thromboplastin reagent comprising: tissue factor, a phospholipid and a polyphosphate that acts as a blocker of tissue factor pathway inhibitor (TFPI). Also provided are a composition for promoting clotting comprising polyphosphate, and a reagent for a clotting assay also comprising polyphosphate together with an activator of clotting. Methods for stopping or slowing wound bleeding and fibrinolysis using compositions comprising polyphosphate are also disclosed.

Description

[0001] Federally funded research or development [0002] This application was funded in part by the following research grants and contracts: NIH (NHLBI and NIAID) Grant Nos. P50 HL45402, R01 HL47014 and R01 AI23259. The United States Government may have rights in this invention. Background technique [0003] Figure 15 is a schematic diagram of the blood coagulation cascade. In the figure, various coagulation factors are indicated by Roman numerals (ie, coagulation factor VII is indicated by VII). When blood comes into contact with certain artificial surfaces, an internal cascade system (also known as the contact pathway of blood coagulation) is initiated. The extrinsic pathway (also known as the tissue factor pathway of blood coagulation) is initiated when vascular injury results in exposure of tissue factor (TF), also known as coagulation factor III. Dashed arrows indicate intersections between the outer and inner pathways. The two pathways converge at the site of activat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/745C12Q1/56
CPCC12Q1/56G01N33/86A61K38/36A61P7/04
Inventor 詹姆斯·H·莫里西斯特凡妮·A·史密斯罗伯托·多卡摩波尼古拉·J·马奇
Owner THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS
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