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Preparation method of enema for curing gynecology inflammation

A technology for gynecological inflammation and enemas, which is applied in the field of preparation of traditional Chinese medicine compositions, can solve the problems of large dosage, low bioavailability, and easy recurrence of the disease, so as to improve bioavailability, improve therapeutic effect, and avoid first-pass effect of effect

Active Publication Date: 2011-07-13
广东德鑫制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the modern medical treatment of gynecological inflammation is mainly treated with antibiotics, but antibiotics often produce drug-resistant bacteria, and the curative effect is not good, which makes the disease prone to repeated attacks
[0003] Fuyankang Tablets is a statutory Chinese patent medicine variety, a national second-class protected variety of traditional Chinese medicine, has a better curative effect on gynecological inflammation, and has a wider clinical application basis; existing Fuyankang Tablets have modified dosage forms such as: Fuyankang Pills, Fuyankang Capsules, Fuyankang Granules, etc. are made by changing the dosage form based on the original Fuyankang Tablet technology. The above dosage forms are all administered orally, with low bioavailability. In clinical use, there are large dosages and slow onset of effects. Shortcomings such as a long course of treatment cannot meet the needs of the majority of patients, and during preparation, the filtrate needs to be concentrated, and the long-term high temperature action causes the active ingredients to decompose and denature. , slow onset, poor therapeutic effect, long course of treatment

Method used

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  • Preparation method of enema for curing gynecology inflammation
  • Preparation method of enema for curing gynecology inflammation
  • Preparation method of enema for curing gynecology inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0129] (1), choose the crude drug of following weight portion: 60 parts of Radix Paeoniae Rubra, 100 parts of Smilax gram, 60 parts of Sanleng (vinegar broiling), 60 parts of Toosendan (stir-frying), 60 parts of Zedoary Curcuma (vinegar broiling), Corydalis Corydalis (roasted with vinegar) 60 parts, Gorgon fruit (stir-fried) 100 parts, angelica 100 parts, flavescens 60 parts, Rhizoma Cyperi (roasted with vinegar) 40 parts, Cortex Phellodendri 60 parts, Salvia miltiorrhiza 100 parts, yam 120 parts, and the Crush Chinese yam and yam into 40-100 mesh fine powder, set aside;

[0130](2), Radix Paeoniae Rubra, Smilax Smilax, Sanleng, Toosendan, Corydalis, Gorgon, Angelica, Sophora, Cyperus Cyperi, Phellodendron Phellodendron, and Red Ginseng are decocted in water three times, adding 5 to 20 times the amount of water for the first time, Decoct for 2 hours, add 5 to 20 times the amount of water for the second time, decoct for 1 hour, add 5 to 20 times the amount of water for the thir...

Embodiment 2

[0138] (1), choose the crude drug of following weight portion: 60 parts of Radix Paeoniae Rubra, 100 parts of Smilax gram, 60 parts of Sanleng (vinegar broiling), 60 parts of Toosendan (stir-frying), 60 parts of Zedoary Curcuma (vinegar broiling), Corydalis Corydalis (roasted with vinegar) 60 parts, Gorgon fruit (stir-fried) 100 parts, angelica 100 parts, flavescens 60 parts, Rhizoma Cyperi (roasted with vinegar) 40 parts, Cortex Phellodendri 60 parts, Salvia miltiorrhiza 100 parts, yam 120 parts, and the Crush Chinese yam and yam into 40-100 mesh fine powder, set aside;

[0139] (2), Radix Paeoniae Rubra, Smilax Smilax, Sanleng, Toosendan, Corydalis, Gorgon, Angelica, Sophora, Cyperus Cyperi, Phellodendron Phellodendron, and Red Ginseng are decocted in water three times, adding 5 to 20 times the amount of water for the first time, Decoct for 2 hours, add 5 to 20 times the amount of water for the second time, decoct for 1 hour, add 5 to 20 times the amount of water for the thi...

Embodiment 3

[0146] (1)~(2) steps are the same as embodiment 1.

[0147] (3) Mix the above-mentioned filtrate with medicinal material fine powder and preservative sodium benzoate 0.5 g / 100mL, add water to dilute to contain 6 grams of the original medicinal material per 100 ml, sterilize, cool, and set aside;

[0148] (4) Aseptically subpackage in 300mL plastic bottles, pack, and obtain liquid type enema;

[0149] (5) If the dry powder type is prepared, the process route includes: concentrating the collected filtrate to a clear paste of a certain density, adding the above-mentioned medicinal material fine powder, stirring evenly, drying, adding an appropriate amount of auxiliary materials, the auxiliary materials used are the same as in Example 1, and crushing , sterilization, packaging and other processes to make dry powder type enema.

[0150] (6) If the dry granule type is prepared, the process route includes: concentrating the collected filtrate to a clear paste of a certain density, a...

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PUM

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Abstract

The invention relates to a preparation method of enemas for gynecological inflammation, which comprises the following steps. Firstly, select a plurality of pharmaceutical ingredients in weight ratio-sixty shares of red peony root, one hundred shares of rhizome smilacis glabrae, sixty shares of rhizoma sparganii, sixty shares of Szechwan chinaberry fruit, sixty shares of rhizome zedoariae, sixty shares of rhizome corydalis, one hundred shares of fried foxnut, one hundred shares of Chinese angelica, sixty shares of light yellow sophora root, forty shares of nutgrass galingale rhizome, sixty shares of amur corktree bark, one hundred shares of Danshen root, and one hundred and twenty shares of Chinese yam. Secondly, grind the rhizome zedoariae and the Chinese yam into fine powder of forty to one hundred meshes for future use, and decoct the rest medicinal herbs with water for three times: at the first time, add water by five to twenty times in weight and decoct for two hours; at the second time, add water by five to twenty times in weight and decoct for one hour; at the third time, add water by five to twenty times in weight and decoct for one hour, and then mix the three decoction solutions and get the filtrate after filtering. Thirdly, concentrate the filtrate. And finally add the fine powder of the rhizome zedoariae and the Chinese yam into the concentrated filtrate to sterilize, cool down and the enema is made. The preparation method can increase the active ingredients of the medicine remarkably, and the medicine combination in the preparation method is characterized in high content of crude drug, and a fast but good therapeutic effect.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine composition for treating gynecological inflammation, in particular to a preparation method of an enema. Background technique [0002] Gynecological inflammation mainly refers to inflammation of female reproductive organs, including female pelvic inflammatory disease, adnexitis, cervicitis, vaginitis, urethritis, etc. caused by various reasons. It is a common gynecological disease, and the prevalence rate of adult women is as high as 80%. Gynecological inflammation can spread to adjacent organs such as the cervix, uterus, and accessories, causing infection; chronic inflammation can also cause infertility or miscarriage. The disease seriously affects women's work, study and life, and brings heavy mental burden and economic pressure to patients, families and society. At present, the modern medical treatment of gynecological inflammation is mainly treated with antibiotics, but...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K9/16A61K36/9066A61P15/00
Inventor 蒋晨光景运条蒋东旭黄鸣清陈长青
Owner 广东德鑫制药有限公司
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