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Steady cisplatin element lipoid plastid and method for preparing the same

A liposome and stable technology, applied in the field of cisplatin-based liposomes, can solve the problems of difficult stability and achieve the effect of improved stability and practical industrial production

Inactive Publication Date: 2008-04-16
吴念 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, its stability problem becomes a big problem

Method used

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  • Steady cisplatin element lipoid plastid and method for preparing the same
  • Steady cisplatin element lipoid plastid and method for preparing the same

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Experimental program
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Effect test

Embodiment 1

[0041] The cisplatin liposome proportioning ratio of the present embodiment is expressed in the following table

[0042] Table 2, cisplatin / platinum oxalate liposome formula

Embodiment 2

[0044] The cisplatin liposome proportioning ratio of the present embodiment is expressed in the following table

[0045] Table 3, cisplatin / platinum oxalate liposome formula

Embodiment 3

[0047] The cisplatin liposome proportioning ratio of the present embodiment is expressed in the following table

[0048] Table 4. Alcisplatin\Oxalplatin Liposome Formula

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Abstract

The present invention relates to a cisplatins liposome and preparation method thereof belonging to pharmaceutical technique field. The composition of the liposome of the present invention can be mixer of fully without phosphorous-containing or partially phosphorous-containing and polyethylene-diglycerides. Because of polyethylene-diglycerides involved, it can greatly decrease inner heat energy generated while liposome forming, thereby increase stability of the liposome. Therefore, the stability of the cisplatins liposome of the present invention is promoted greatly, it can be preserved long time under proper temperature, its industrial production is practicable.

Description

technical field [0001] The invention relates to a cisplatin-like liposome and a preparation method, belonging to the technical field of pharmacy. Background technique [0002] Cisplatin is a very effective antineoplastic drug used in the systemic treatment of germ cell cancer, mainly for endometrial cancer, bladder, ovarian and testicular tumors, and head and neck cancer. Like other antineoplastic drugs, cisplatin is a highly toxic drug, and its main disadvantage is severe damage to the kidneys, so the dosage is limited. Cisplatin is rapidly excreted by the kidneys, and its circulation period is only a few minutes, with a strong affinity for plasma proteins. Clinically, combined chemotherapy is used to reduce the side effects of cisplatin, and cisplatin is chemically derivatized and modified and liposome encapsulation technology is used. [0003] Carboplatin is a new generation chemical derivative of cisplatin. Because carboplatin has less side effects than cisplatin, esp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/194A61K33/24A61K47/34A61P35/00A61K47/14A61K47/28
Inventor 吴念王二新
Owner 吴念
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