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Preparation method of shell core fibre tectorial membrana endovascular stent

An inner stent and fibrous membrane technology, applied in stents, medical science, surgery, etc., can solve problems affecting treatment goals, achieve good biological safety and mechanical properties, easy industrial production, and prevent blood supply.

Inactive Publication Date: 2008-04-09
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Intravascular stents can support stenotic and occluded blood vessels to achieve the purpose of maintaining smooth blood flow in the lumen, but restenosis after stent placement seriously affects the goal of treatment

Method used

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  • Preparation method of shell core fibre tectorial membrana endovascular stent
  • Preparation method of shell core fibre tectorial membrana endovascular stent

Examples

Experimental program
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Effect test

preparation example Construction

[0031] The preparation method of the shell-core fiber-coated intravascular stent of the present invention, the specific steps are as follows:

[0032] (1) dissolving the natural or artificial polymer in a suitable solvent to obtain a homogeneous solution with a concentration of 0.01-0.08 g / ml;

[0033] (2) Dissolving the drug or artificial polymer with the drug and bioactive ingredients in a suitable solvent to obtain a uniform solution or suspension, or preparing the solutions separately and mixing them into a uniform solution or suspension;

[0034] (3) As shown in Figure 1, add the homogeneous solution of natural or artificial polymer and the solution or suspension of medicine or artificial polymer and medicine, biological activity to two syringes 1 and 2 respectively, and adjust the speed of micro-injection pump 3 0.1-5.0 ml / hour, adjust the high-voltage electrostatic generator 7 so that the voltage is 5000-30000 volts, adjust the receiving device so that the receiving dis...

example 1

[0043] (1) preparing a solution with a heparin concentration of 0.08 g / ml, the solvent used is water;

[0044] (2) Prepare a solution of P(LLA-CL) with a concentration of 0.06 g / ml, and the solvent used is hexafluoroisopropanol.

[0045] (3) Put the heparin solution into the supply syringe of the inner layer, put the P(LLA-CL) solution into the supply syringe of the outer layer, and adjust the supply rate of the inner and outer layers to 0.1 ml / hour and 0.9 ml / hour. Electrospinning is carried out under the action of a propulsion pump and a high-voltage electrostatic generator to obtain heparin-containing fibers with a shell-core structure;

[0046] (4) Fix the intravascular stent on the rotating shaft with a voltage of 20.0 kV, a receiving distance of 20.0 cm, and a motor speed of 50 rpm. After 30 minutes, the intravascular stent is covered with a fibrous membrane with a thickness of about 0.10 mm;

example 2

[0048] (1) the preparation paclitaxel concentration is the solution of 0.01 g / ml, and the solvent used is acetone;

[0049] (2) Prepare a solution of P(LLA-CL) with a concentration of 0.06 g / ml, and the solvent used is trifluoroethanol.

[0050] (3) put the paclitaxel solution into the supply syringe of the inner layer, put the P(LLA-CL) solution into the supply syringe of the outer layer, and adjust the supply rate of the inner and outer layers to be 0.3 ml / hour and 0.9 ml / hour. Electrospinning is carried out under the action of a propulsion pump and a high-voltage electrostatic generator to obtain paclitaxel-containing fibers with a shell-core structure;

[0051] (4) Fix the intravascular stent on the rotating shaft with a voltage of 15.0 kV, a receiving distance of 15.0 cm, and a motor speed of 100 rpm. After 30 minutes, the intravascular stent is covered with a fibrous membrane with a thickness of about 0.10 mm.

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Abstract

The invention relates to a preparation method of a shell core fiber covered endovascular stent graft. The steps are as follows: firstly, a polymer is dissolved in adaptive dissolvent to obtain solution with a certain concentration; secondly, medicine or an artificial polymer and medicine, and a bio-active element are dissolved in the adaptive dissolvent to obtain solution or suspension liquid; thirdly, the solution of the polymer and the medicine or the solution or suspension liquid of the medicine or bio-active element are respectively filled in two injectors, the speed of a micro injection pump, the voltage of an electrostatic generator and the distance of a receiving device are adjusted, fiber is obtained through the static spinning preparation, and the fiber is received as a tube shape or film shape structure; fourthly, the endovascular stent graft is fixed on a revolution axle, through the revolution of the endovascular stent graft, the static spinning fiber are directly received as fibrous membrane covered on the endovascular stent graft. The invention can effectively prevent smooth muscle cells from hyperplasia in the stent graft or from narrowing in the stent graft caused by the other functions, and the shell core fiber for the medicine loading can slowly release the medicine to attain the purpose of curing.

Description

technical field [0001] The invention belongs to the field of minimally traumatic interventional medical products, and in particular relates to a preparation method of an intravascular stent with an electrospun shell-core fiber layer coating. Background technique [0002] Electrospinning is an easy way to create nanofibers by charging a polymer solution or melt, which can be ejected and ultimately produced. The fiber diameter of natural or synthetic polymers prepared by electrospinning technology can reach tens of nanometers to hundreds of nanometers. Materials that have been successfully prepared include chitosan, collagen, polyurethane, polyvinyl alcohol, polylactic acid and other synthetic and natural materials. On the basis of general electrospinning, in recent years, coaxial co-spinning has been developed to prepare fibers with a shell-core structure. For example, Huang Zhengming et al. reported a coaxial composite continuous nano / micro fiber material and its preparation...

Claims

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Application Information

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IPC IPC(8): A61L31/08A61L31/06A61F2/82
Inventor 莫秀梅陈锋何创龙王红声
Owner DONGHUA UNIV
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