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Method of preparing diclazuril microemulsion

A technology of diclazuril and microemulsion, which can be used in emulsion delivery, anti-infective drugs, active ingredients of heterocyclic compounds, etc. Improves bioavailability, prolongs residence time, and reduces usage

Inactive Publication Date: 2008-04-02
杨水新
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The production process of diclazuril microemulsion oral liquid currently on the market uses a large amount of organic solvents to dissolve, which is highly irritating, has obvious adverse pharmacological effects, and high cost; The duration of the effect is short, which affects the effect of drug use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A diclazuril microemulsion is made by the following method:

[0027] (1). Take 0.5 g of diclazuril, add 3 ml of Tween-80, and stir well;

[0028] (2). Add DMF24ml and stir well;

[0029] (3). Add 10ml of glycerol methylal and stir well;

[0030] (4). Add 1ml of ethanolamine and stir well;

[0031] (5). Add water to 100ml and stir to form a diclazuril microemulsion solution.

Embodiment 2

[0033] A diclazuril microemulsion is made by the following method:

[0034] (1). Take 1 g of diclazuril, add 5 ml of Tween-80, and stir well;

[0035] (2). Add DMF40ml and stir well;

[0036] (3). Add 5ml of glycerol methylal and stir well;

[0037] (4). Add 5ml of ethanolamine and stir well

[0038] (5). Add water to 100ml and stir to form a diclazuril microemulsion solution.

Embodiment 3

[0040] A diclazuril microemulsion is made by the following method:

[0041] (1). Take 0.8 g of diclazuril, add 4 ml of Tween-80, and stir well;

[0042] (2). Add DMF30ml and stir well;

[0043] (3). Add 15ml of glycerol methylal and stir well;

[0044] (4). 1ml of triethanolamine, stir well;

[0045] (5). Add water to 100ml and stir to form a diclazuril microemulsion solution.

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Abstract

The invention relates to the preparation method of a Diclazuril microemulsion. The preparation method is: (1) Diclazuril is put in tween-80 and stirred evenly; (2) Dimethylformamide is added in and stirred evenly; (3) glycerin and dimethoxymethane is added in and stirred evenly; (4) ethanolamine or triethanolamine is added in and stirred evenly; (5) water is added in and stirred evenly, and then the Diclazuril microemulsion is prepared. The invention adopts advanced microemulsion technology and slightly water soluble Diclazuril is prepared into Siclazuril microemulsion solution which is soluble with water in any ratio. The method greatly enhances the bioavailability of the product, prolongs the residence time of medicine in human body, and reduces the volume of use of drug. Compared with traditional solutions, the product greatly reduces the volume of use of organic solution and has reliable safety, few side effects, low toxicity, high treating effects, so is applicable to treat diseases caused by coccidian. Besides, the microemulsion can be directly taken after being mixed with water and the use is very convenient.

Description

technical field [0001] The invention belongs to the field of microemulsion preparations, in particular to a preparation method of diclazuril microemulsion. Background technique [0002] Diclazuril is one of the most commonly used anticoccidial drugs, and it is also the anticoccidial drug with the lowest concentration so far, but diclazuril has little solubility in water. At present, the production process of diclazuril microemulsion oral liquid on the market uses a large amount of organic solvent to dissolve, which is highly irritating, has obvious adverse pharmacological effects, and has high cost; and it is easy to separate out when diluted, and the drug has poor dispersibility and low bioavailability. The duration of effect is short, which affects the effect of drug use. SUMMARY OF THE INVENTION [0003] The purpose of the present invention is to overcome the deficiencies of the prior art and provide a preparation method of diclazuril microemulsion with a longer durati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/53A61K9/107A61K47/34A61P33/02A61K47/26
Inventor 杨水新
Owner 杨水新
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