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Composition extracted from tubiflorae cistanche salsa, use thereof and method of extracting the same

A technology of Cistanche deserticola tuberosa and its composition, which is applied in the direction of chemical instruments and methods, drug combinations, medical preparations containing active ingredients, etc., can solve the problems of limited utilization of active ingredients, separate application, and low content of ingredients, and is easy to industrialize. Popularization and application, obvious treatment of high blood pressure, good extraction effect

Inactive Publication Date: 2008-02-27
新疆维吾尔自治区中药民族药研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, traditional processing methods such as soaking and boiling are mainly used when being used as medicine at present, and the utilization of its active ingredients is very limited.
In particular, what is extracted by traditional processing is a mixture, and various active ingredients in it cannot be separated during use, and are applied separately for specific objects, resulting in waste of active ingredients. On the other hand, due to the various ingredients Mixed, so one of them has a low content of specific ingredients, and its performance is difficult to be well exerted

Method used

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  • Composition extracted from tubiflorae cistanche salsa, use thereof and method of extracting the same
  • Composition extracted from tubiflorae cistanche salsa, use thereof and method of extracting the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Raw material preparation: Take 100Kg of dry medicinal material of Cistanche tuberosum and crush it to granules of ≤0.3mm for later use;

[0052] Extraction: 4 times with 10 times the weight of Cistanche tuberosum and 90% ethanol for 5 days each time, after each extraction, filter with a 149цm filter to get the filtrate;

[0053] Concentration: depressurize the obtained filtrate to boiling at a temperature of 55°C, and concentrate to a total weight of 80Kg;

[0054] Extraction: extract 5 times with ethyl acetate, the amount of ethyl acetate used for each extraction is 120Kg, after layering, discard the ethyl acetate part, depressurize to boiling at a temperature of 55°C and concentrate to a water content of 30% to obtain an extract ;

[0055] Water precipitation: add the obtained extract to the top of the macroporous resin column with a particle size of 5000Kg and a particle size of 0.5mm, and wash it with ethanol solutions with a concentration of 10%, 20%, 30%, and 40%...

Embodiment 2

[0067] Raw material preparation: Take 100Kg of dry medicinal material of Cistanche tuberosum and crush it to granules ≤ 3.0mm for later use;

[0068] Extraction: leaching 3 times with 80% ethanol which is 4 times the weight of Cistanche tubulosa medicinal material, and leaching for 6 days each time. After each leaching, filter with a 250цm filter to get the filtrate;

[0069] Concentration: depressurize the filtrate obtained from the extraction to boiling at a temperature of 55°C, and concentrate until the total amount is less than 90Kg;

[0070] Extraction: extract twice with ethyl acetate, the amount of ethyl acetate used for each extraction is 350Kg, after layering, discard the ethyl acetate part, depressurize to boiling at a temperature of 55°C and concentrate to a water content of 28% to obtain an extract ;

[0071] Water precipitation: Add the obtained extract to the top of a macroporous resin column with a particle size of 0.5mm and 800Kg, and wash it with ethanol solu...

Embodiment 3

[0074] Raw material preparation: Take 100Kg of dry medicinal material of Cistanche tuberosum and crush it to granules of ≤1mm for later use;

[0075] Extraction: leaching 5 times with 85% ethanol which is 6 times the weight of Cistanche tuberosum medicinal material, leaching for 4 days each time, filtering with a 149цm filter screen after each leaching, and taking the filtrate;

[0076] Concentration: depressurize the obtained filtrate to boiling at a temperature of 50°C, and concentrate to a total weight of 80Kg;

[0077] Extraction: extract 4 times with ethyl acetate, use 100Kg of ethyl acetate for each extraction, discard the ethyl acetate part after layering, depressurize to boiling at a temperature of 45°C and concentrate to a water content of 25% to obtain an extract;

[0078] Water precipitation: add the obtained extract to the top of a macroporous resin column with a particle size of 3000Kg and a particle size of 0.3mm, and wash it with ethanol solutions with a concent...

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Abstract

The invention discloses a composition extracted from Cistanche deserticola and application of drug composition and extracting method, which comprises the following steps: preparing raw material; lixiviating through alcohol; condensing; extracting; doing water sedimentation; drying; dehydrating; filtering through macropore resin. The invention increases the content of pineal glycoside and ergosterin steroid glycoside to 56. 3% and 9. 78% respectively, which can treat hypertension obviously.

Description

Technical field: [0001] The present invention relates to a composition extracted from Cistanche tubulosa and its use and extraction method, especially a composition containing echinacoside and ergosteroside extracted from Cistanche tubulosa and its The medicinal application mainly composed of the composition for treating hypertension and the extraction method of the composition. Background technique: [0002] Cistanche tubulosa [Cistanche tubulosa (Schenk) Wight.] is a perennial parasitic plant of the genus Cistanche in the family Cistanche. It is generally used as a nourishing medicine. , sugar three parts, including echinacoside, ergosteroside, cistanche glycosides and other substances. [0003] The currently known pharmacological effects have the functions of invigorating kidney yang, benefiting essence and blood, moistening intestines and defecating, and are used for impotence, infertility, soreness of the waist and knees, weakness of muscles and bones, intestinal irrit...

Claims

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Application Information

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IPC IPC(8): A61K36/64A61P9/12C07H1/08
Inventor 熊元君贾晓光李勇谢海辉
Owner 新疆维吾尔自治区中药民族药研究所
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