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Traditional Chinese medicinal composition for protecting gastric mucosa and its preparation method

A composition and technology of gastric mucosa, applied in the field of traditional Chinese medicine composition for protecting gastric mucosa and its preparation, to achieve the effects of enhanced curative effect, reasonable and convenient process, and retention of active ingredients

Active Publication Date: 2008-02-13
ZHEJIANG YAKE SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no ideal drug for treating chronic atrophic gastritis at home and abroad

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Weigh 30kg of plantain and dandelion according to the ratio of 1:0.2, add 10 times the amount of water to soak for 0.5h, decoct twice, 2h each time, combine the decoction after filtering, and concentrate under reduced pressure to a relative density of 1.05 at 60°C Add 95% ethanol to the concentrated solution, mix evenly, adjust the alcohol content to 60%, let stand at 4°C-8°C for 24h, filter with 400 mesh filter cloth, wash the precipitate with 60% ethanol, filter, and combine the filtrates, Recover ethanol under reduced pressure, continue to concentrate under reduced pressure to a thick paste with a relative density of 1.35 at 60°C, add 20% starch (w / w) to mix, vacuum dry, grind into fine powder, add 2kg starch, 2kg microcrystalline cellulose , 0.3kg sodium carboxymethyl starch, mix well, use 3% povidone K30 ethanol solution as binder, wet granulate, dry, add 0.3kg sodium carboxymethyl starch and 0.3kg talcum powder, mix well, press tablet .

Embodiment 2

[0023] Weigh 30kg of plantain and dandelion according to the ratio of 1:0.5, add 10 times the amount of water to soak for 0.5h, decoct 3 times for extraction, each time for 1h, combine the decoction after filtration, concentrate under reduced pressure to a relative density at 60°C of For the concentrated solution of 1.10, add 95% ethanol and mix well, adjust the alcohol content to 65%, let stand at 4°C-8°C for 30h, filter with 400 mesh filter cloth, wash the precipitate with 65% ethanol, filter, and combine the filtrates , Recover ethanol under reduced pressure, continue to concentrate under reduced pressure to a thick paste with a relative density of 1.32 at 60°C, dry, grind into fine powder, mix with 5kg soluble starch and 20kg sucrose powder, and make granules.

Embodiment 3

[0025] Weigh 30kg of plantain and dandelion according to the ratio of 1:2, add 10 times the amount of water to soak for 0.5h, decoct 3 times for extraction, each time for 1h, combine the decoction after filtration, concentrate under reduced pressure to a relative density of For the concentrated solution of 1.15, add 95% ethanol and mix well, adjust the alcohol content to 70%, let stand at 4°C-8°C for 36 hours, filter with 400 mesh filter cloth, wash the precipitate with 70% ethanol, filter, and combine the filtrates , reclaim ethanol under reduced pressure, continue to concentrate under reduced pressure to a thick paste with a relative density of 1.30 at 60°C, add 50% starch (w / w) and mix, dry, pulverize and pass through an 80-mesh sieve, and pack into capsules.

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Abstract

The present invention discloses a Chinese medicine compound for gastric mucosa protection and the preparation method. The plantaginis and the dandelion are taken as the raw materials in the compound, which are mixed with the excipient into an oral preparation after extraction with the ethanol subsiding method or the alcohol extraction and decompression of the recycling recycling. The present invention has synergistic interaction function. Single application of the plantaginis and the dandelion both have gastric mucosa protection function, which have a synergistic interaction function after combination and the treatment effect can increase dramatically. The technique process is simple and convenient. The active part can be maintained as much as possible. The present invention has a good protection and treatment function for the acute gastric mucosa injury, the chronic gastric mucosa injury and the chronic atrophic gastritis.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for protecting gastric mucosa and a preparation method thereof. Background technique [0002] The stomach is the most enlarged part of the digestive tract, and the stomach capacity of an adult is about 3000ml. The digestive function of the stomach is mainly accomplished by mechanical and chemical actions. As the part of the stomach that is in most contact with food, the gastric mucosa is prone to problems. Under normal circumstances, mucosal protective factors such as mucus secreted by gastric mucosa and gastric mucosal surface epithelium can protect gastric mucosa from mechanical friction, thermal stimulation, gastric acid, pepsin, bacteria and other mucosal attack factors, thereby preventing gastric mucosal damage. However, often due to factors such as modern people's fast work pace, mental stress, heavy drinking, smoking, long-term drinking of strong tea, irregular diet, and drug ...

Claims

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Application Information

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IPC IPC(8): A61K36/68A61K9/16A61K9/20A61K9/48A61P1/04
Inventor 金圣煊孙静芸雷荣剑林燕飞晏桂敏
Owner ZHEJIANG YAKE SCI & TECH
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