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Articular cavity inner injecting and administering reparations containing trehalose

A technology of trehalose and joint cavity, applied in the field of medicine, can solve the problems of slow effect and difficult curative effect

Active Publication Date: 2008-01-30
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although oral administration of trehalose has a certain effect on improving arthritis and has no adverse reactions, the effect of oral administration is slow, and it is difficult to obtain a good curative effect in a short period of time.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: A kind of liquid preparation for intra-articular injection

[0012] Party:

[0013] Element

Embodiment 2

[0014] Embodiment 2: A kind of gel for intra-articular injection

[0015] Party:

[0016] Element

[0017] Sodium chloride

Embodiment 3

[0018] Embodiment 3: A kind of liquid preparation for intra-articular injection

[0019] Party:

[0020] Element

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PUM

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Abstract

The present invention provides an intra-articular injection administration preparation containing trehalose, which is characterized in that the preparation contains the trehalose. The present invention can improve the capabilities of the cartilage cells to adapt to and resistant to the environmental changes through the intra-articular injection administration, at the same time, the trehalose has the significant effects of antioxidant and anti-free radicals, which can alleviate the symptoms of arthritis; in addition, the trehalose also provides the necessary sugar for cartilage repair, so as to repair and reconstruct the cartilage. The present invention is used for improving and treating the rheumatism, rheumatoid arthritis, osteoarthritis, synovitis and / or cartilage injury.

Description

Technical field: [0001] The invention belongs to the technical field of medicine and provides a preparation for intra-articular injection containing trehalose. Background technique: [0002] Arthritis is one of the common joint diseases clinically, which is more common in the elderly. With the prolongation of the average human life span and the continuous aggravation of the aging society, the incidence of arthritis in the elderly is also increasing, which seriously reduces the quality of life of the elderly. Therefore, the treatment of arthritis has become a major problem to be solved urgently. [0003] Arthritis caused by various reasons starts from the degeneration and damage of articular cartilage, followed by the changes of bone and synovium. The degeneration of cartilage includes the changes of chondrocytes and matrix. In arthritis patients, damage to articular chondrocytes leads to environmental sensitivity, especially to changes in temperature. At present, there ar...

Claims

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Application Information

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IPC IPC(8): A61K31/7016A61K31/728A61K31/737A61P29/00A61P19/02
CPCA61K9/0024A61K47/26A61K31/7016A61K9/0019A61P19/02A61P29/00
Inventor 凌沛学荣晓花
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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