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Epimedium erigeron pharmaceutical composition

A composition and medicine technology, applied in the field of medicine, achieves the effects of uniform and stable medicine quality, reducing relative dosage and ensuring safety

Inactive Publication Date: 2008-01-23
SHANDONG XUANZHU PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, the interaction between the total flavonoids of Epimedium and the extract of breviscapine or breviscapine is used to prepare the medicine for treating cardiovascular and cerebrovascular diseases, which has not been reported yet.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0123] The preparation of embodiment 1 epimedium total flavonoids

[0124] Preparation technology of total flavonoids of Epimedium

[0125] Weigh Epimedium medicinal material, add water to decoct twice, each time for 1.5 hours, add 10 times of water each time, combine the decoction, filter, put the filtrate in cold storage overnight, filter, concentrate the filtrate to a relative density of 1.08-1.10 Concentrate, add ethanol until the alcohol content is 60%, stir evenly, refrigerate and stand for 24 hours, filter, concentrate the filtrate to a relative density of 1.03-1.05, add to the treated polyamide resin (80-100 mesh) On the column, first wash with 3 to 4 times column volume of water, then wash with 2 to 3 times column volume of 20% ethanol, discard the washing solution, and then use 4 to 5 times column volume of 95% ethanol to elute. The eluate is collected, ethanol is recovered, and spray-dried to obtain total flavonoids of Epimedium.

[0126] Identification of Total...

Embodiment 2

[0139] The preparation of embodiment 2 scutellaria breviscapus extract

[0140] Preparation process of Erigeron breviscapus extract

[0141] Take scutellaria breviscapus medicinal material, add water to decoct twice, decoct for 1.5 hours each time, add 10 times the amount of water, combine the extracts, filter, concentrate the filtrate to a relative density of 1.10-1.12 (50°C), add ethanol to the alcohol content to 60%, stirred, refrigerated and stood still for 12 hours, filtered, and the filtrate was decompressed to recover ethanol to a relative density of 1.12-1.15 (50°C), adjusted the pH value to 2 with hydrochloric acid, kept at 55°C for 6 hours, filtered, The filtrate passes through a polyamide column, first washes away impurities with water, and then elutes with 90% ethanol, collects the ethanol liquid, recovers the ethanol under reduced pressure and concentrates it to a thick paste, dries, and pulverizes to obtain a medicinal powder; the precipitate is washed with 20%...

Embodiment 3

[0152] Embodiment 3: Preparation of sheepskin breviscap composition powder injection

[0153] prescription:

[0154] Prescription 1:

[0155] Epimedium Total Flavonoids 100g

[0156] Breviscapus extract 60g

[0157] Polysorbate 80 60g

[0158] Mannitol 300g

[0159] Add sterile water for injection to 3000ml

[0160]

[0161] A total of 1000 sticks were prepared

[0162] Prescription 2:

[0163] Epimedium Total Flavonoids 100g

[0164] Breviscapine 10g

[0165] Polysorbate 8060g

[0166] Mannitol 300g

[0167] Add sterile water for injection to 3000ml

[0168]

[0169] A total of 1000 sticks were prepared

[0170] Preparation Process:

[0171] 1) First, aseptically process the containers used for liquid preparation, antibiotic glass bottles, rubber stoppers, etc.

[0172] 2) Weigh the raw materials and auxiliary materials according to the prescription quantity. ...

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PUM

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Abstract

The invention belongs to the technical field of medical technology and discloses a drug compound for treating cardio cerebrovascular diseases as well as its preparation method, which comprises the flowing ingredients: epimedium total flavone of 10 to 600 shares, erigeron breviscapus extract of 5 to 450 shares, breviscapinun of 2 to 50 shares and pharmaceuatically acceptable supplementary materials. The ingredients are mixed to make acceptable formulations, preferably injection and oral formulation. The combination of injection and oral formulation will enhance the curative effect to a great extent.

Description

【Technical field】 [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for cardiovascular and cerebrovascular diseases and a preparation method thereof. 【Background technique】 [0002] Cardiovascular and cerebrovascular diseases have always been known as the number one killer that threatens human health. According to relevant survey reports, there are more than 3 million people who die from cardiovascular and cerebrovascular diseases in my country every year, accounting for 50% of the total number of deaths in my country every year. 75% of people are disabled to varying degrees, and 4% are severely disabled, especially the age of onset and death is becoming younger. How to effectively prevent and treat cardiovascular and cerebrovascular diseases has attracted great attention. [0003] Cardiovascular and cerebrovascular diseases include coronary heart disease, angina pectoris, myocardial infarction, blood s...

Claims

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Application Information

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IPC IPC(8): A61K36/296A61K36/28A61K31/365A61K31/7048A61K9/08A61P9/10A61P9/12
Inventor 黄振华
Owner SHANDONG XUANZHU PHARMA TECH CO LTD
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