Benzofuran derivative and application thereof
A technology of benzofuran and its derivatives, which is applied in the direction of drug combinations, plant raw materials, medical preparations containing active ingredients, etc., and can solve the problem of not finding ingredients with particularly significant activity
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example 1
[0069] Example 1: Extraction and separation of the compound of the present invention from the branch of Prunus chinensis.
[0070] Dried the whole herb [Lespedeza virgata (Thurb)] DC 40kg with the stalks of stalks, crushed, extracted by percolation with 95% ethanol, combined the extracts, recovered the ethanol in the extracts to obtain extracts, and the obtained extracts were firstly used with petroleum ether Extraction, take the water phase, then extract with chloroform, take the water phase, then extract with ethyl acetate, take the water phase, and finally extract with n-butanol, pass the n-butanol part through the forward silica gel column, and use the volume ratio respectively 98:2 , 95:5, 9:1 mixture of chloroform and methanol for gradient elution, collect the eluate with a volume ratio of chloroform and methanol of 9:1, and perform ODS reverse column chromatography, using concentrations of 30%, 50%, and 60% methanol gradient elution, collect the eluate of 60% methanol, ...
example 2
[0075] Example 2: (injection)
[0076] The compound obtained in Example 1 was made into an injection by the preparation method of a medicinal injection: 1000 mg of the compound was dissolved in 1000 ml of normal saline, heated to dissolve, mixed evenly, poured into a bottle, sealed, and sterilized to make 2 mg / 2 ml One injection. This product is used for intravenous injection (iv.), 6mg / day for adults, equivalent to 3 vials; usual dose for children: 0.05mg / kg / day based on body weight.
example 3
[0077] Example 3: (injection)
[0078] The compound obtained in Example 1 was prepared as an injection by the preparation method of a medicinal injection. Dissolve 2000 mg of this compound in 1000 ml of normal saline, heat to dissolve, mix well, pour into a bottle, seal, and sterilize to make 4 mg / 2 ml One injection. This product is used for intravenous injection (iv.), 6mg / day for adults, equivalent to 1.5 vials; usual dose for children: 0.05mg / kg / day according to body weight.
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