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Active carbon intestinal bioadhesive preparation and preparation method thereof

A technology of bioadhesion and activated carbon, which is applied in the direction of antivirus, pill delivery, drug combination, etc., to achieve remarkable curative effect

Inactive Publication Date: 2007-12-12
THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since its principle of action lies in adsorption, activated carbon needs to be fully in contact with the intestinal mucosa and needs to be maintained in the intestinal tract for a long time in order to better exert its curative effect; and its ordinary tablet does not have these characteristics

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Tablets (or capsules, pills, granules) made by methods known in the pharmaceutical industry contain the following components by weight percentage:

[0061] Activated Charcoal 75%

[0062] Hypromellose 14.5%

[0063] Sodium Carboxymethyl Starch 5%

[0064] 3% hypromellose aqueous solution appropriate amount

[0065] Magnesium Stearate 0.5%

[0066] Novel acrylic resin 5%

[0067] Preparation method:

[0068] 1. Take hypromellose and sodium carboxymethyl starch in a proportioning amount, and mix thoroughly to obtain a mixture of auxiliary materials;

[0069] 2. Take the proportioned amount of activated carbon, add the auxiliary material mixture in the previous step, and mix well;

[0070] 3. Take a proportioned amount of 3% hypromellose aqueous solution and add it to the mixture in the previous step, and stir while adding to make a soft material;

[0071] 4. Make the soft material from the previous step into wet granules by using the existing pharmaceutical industr...

Embodiment 2

[0076] Capsules (or granules, pills, tablets) made by methods known in the pharmaceutical industry contain the following components by weight percentage:

[0077] Activated Charcoal 65%

[0078] Chitosan 14.5%

[0079] Microcrystalline Cellulose 10%

[0080] Crosslinked PVP 5%

[0081] 3% hypromellose aqueous solution appropriate amount

[0082] Magnesium Stearate 0.5%

[0083] Preparation method:

[0084] 1. Take chitosan, microcrystalline cellulose and cross-linked PVP in a proportioning amount, and mix them thoroughly to obtain a mixture of auxiliary materials;

[0085] 2. Take the proportioned amount of activated carbon and add the auxiliary material mixture in the previous step;

[0086] 3. Take the proportioned amount of binder and add it to the mixture in the previous step, and stir while adding to make a soft material;

[0087] 4. Make the soft material from the previous step into wet granules by using the existing pharmaceutical industry technology;

[0088] 5...

Embodiment 3

[0092] Granules (or capsules, pills, tablets) made by methods known in the pharmaceutical industry contain the following components by weight percentage:

[0093] Activated carbon 80%

[0094] Carbomer 10%

[0095] Sodium Carboxymethyl Starch 5%

[0096] 3% hypromellose aqueous solution appropriate amount

[0097] Novel acrylic resin 5%

[0098] Preparation method:

[0099] 1. Take the proportioning amount of carbomer and sodium carboxymethyl starch, and mix thoroughly to obtain the auxiliary material mixture;

[0100] 2. Take the proportioned amount of activated carbon, add the auxiliary material mixture in the previous step, and mix well;

[0101] 3. Take a proportioned amount of 3% hypromellose aqueous solution and add it to the mixture in the previous step, and stir while adding to make a soft material;

[0102] 4. Make the soft material from the previous step into wet granules by using the existing pharmaceutical industry technology;

[0103] 5. Dry the wet granule...

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PUM

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Abstract

The invention provides a biologic adhesion preparation of active carbon for bowels and its preparation method. The preparation comprises (by weight percentage) active carbon 30-90%, adjuvant with biologic adhesion function 10-70%, and other adjuvant in balance. Adjuvant with biologic adhesion function is hydroxypropyl methyl cellulose and / or chitosan and / or carbomer and / or polycarbophil and / or ethyl acrylate and / or carbopol. The preparation method comprises mixing active carbon with medicinal adjuvant including biologic adhesionagent, bulking agent and lubricant, preparing into core material, coating with one or multi-layer enteric coat or filling in enteric-coated capsules. The invention can be prepared into pill, tablet, granule, or capsule. Compared with common active carbon preparation, the preparation can be directly transmitted to duodenum and generate biologic adhesion with intestinal wall after oral administration, has intestinal location and sustained release, can improve therapeutic effect, reduce administeration dose and times. The inventive preparation is mainly used for treating chronic rnal failure, drug poisoning, and acute / chronic lead poisoning.

Description

technical field [0001] The invention relates to an active carbon intestinal bioadhesive preparation for treating chronic renal failure, drug poisoning, and acute and chronic lead poisoning and a preparation method thereof. Background technique [0002] Activated carbon is a broad-spectrum adsorbent that can adsorb many substances. It is widely used in chemical engineering, environmental engineering and other fields. In recent years, with the advancement of material technology and preparation technology, activated carbon has gradually increased in clinical applications, especially in hemoperfusion. Substantial progress has been made; its common tablets are widely used clinically, mainly for the treatment of chronic renal failure, drug poisoning, and acute and chronic lead poisoning. Since the principle of action lies in adsorption, activated carbon needs to be fully in contact with the intestinal mucosa and needs to be maintained in the intestinal tract for a long time in ord...

Claims

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Application Information

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IPC IPC(8): A61K33/44A61K9/16A61K9/20A61K9/48A61P13/12A61P39/02
Inventor 肖平方平飞
Owner THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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