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Skin whitening preparation for external use, whitening preparation, whitening method and method of producing skin whitening preparation for external use

A technology of skin external preparation and whitening agent, which is applied in the field of skin whitening external preparations, can solve the problems of slow appearance, skin allergy, insufficient effect, etc., and achieve the effect of excellent safety performance and excellent safety performance.

Inactive Publication Date: 2007-11-28
SHISEIDO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, compounds other than hydroquinone that inhibit the activity of tyrosinase show their effects very slowly, so the effect of improving skin pigmentation is not sufficient
On the other hand, the effect of hydroquinone has been recognized, but its irritant can cause skin allergies, so its use is generally restricted

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Example 1: Cream

[0073] (formulation) (mass%)

[0074] Stearic acid 5.0

[0075] Stearyl Alcohol 4.0

[0076] Isopropyl myristate 18.0

[0077] Glyceryl Monostearate 3.0

[0078] Propylene glycol 10.0

[0079] Ethanol Extract of Corrugated Water Flower 0.01

[0080] Potassium hydroxide 0.2

[0081] Sodium bisulfite 0.01

[0082] Appropriate amount of preservatives

[0083] Appropriate amount of spices

[0084] Ion-exchanged water balance

[0085] (Preparation)

[0086] Propylene glycol, the ethanol extract of the cold water flower and potassium hydroxide were added to the ion-exchanged water to dissolve them, and the mixture was heated and kept at 70°C (aqueous phase). After mixing other components, heat and dissolve them, and maintain 70 degreeC (oil phase). Slowly add the oil phase to the water phase, and keep the temperature for a while after all the addition to allow the reaction to proceed. Thereafter, it was uniformly emulsified using a homomixer, a...

Embodiment 2

[0087] Example 2: Cream

[0088] (formulation) (mass%)

[0089] Stearic acid 2.0

[0090] Stearyl Alcohol 7.0

[0091] Hydrogenated Lanolin 2.0

[0092] Squalane 5.0

[0093] 2-Octyldodecanol 6.0

[0094] Polyethylene oxide (25 moles) cetyl ether 3.0

[0095] Glyceryl Monostearate 2.0

[0096] Propylene Glycol 5.0

[0097] Tribasin hexane extract 0.05

[0098] Sodium bisulfite 0.03

[0099] Ethyl p-hydroxybenzoate 0.3

[0100] Appropriate amount of spices

[0101] Ion exchanged water balance

[0102] (Preparation)

[0103] Add propylene glycol to ion-exchanged water, heat and maintain 70°C (water phase). The other ingredients were mixed, then heated to dissolve and kept at 70°C (oil phase). The oil phase was added to the water phase and preliminarily emulsified, then, it was uniformly emulsified using a homomixer, and the temperature was cooled to 30° C. while fully stirring.

Embodiment 3

[0104] Example 3: Cream

[0105] (formulation) (mass%)

[0106] Paraffin wax 5.0

[0107] Beeswax 10.0

[0108] Vaseline 15.0

[0109] Liquid paraffin 41.0

[0110] Glyceryl Monostearate 2.0

[0111] Polyethylene oxide (20 moles) sorbitan monolaurate 2.0

[0112] Soap powder 0.1

[0113] Borax 0.2

[0114] Acetone Extract of Melissa officinalis 0.05

[0115] Sodium bisulfite 0.03

[0116] Ethyl p-hydroxybenzoate 0.3

[0117] Appropriate amount of spices

[0118] Ion-exchanged water balance

[0119] (Preparation)

[0120] Add soap powder and borax to ion-exchanged water, heat to dissolve and keep at 70°C (water phase). After mixing other components, it heated and melt|dissolved, and kept 70 degreeC (oil phase). Stir the oil phase while slowly adding it to the water phase for reaction. After the reaction, use a homogeneous mixer to emulsify evenly. After emulsification, fully stir while cooling the temperature to 30°C.

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PUM

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Abstract

An external preparation for skin whitening containing 0.001 to 20.0 mass % of an extract of at least one plant selected from the group consisting of Pilea cavaleriei (Urticaceae), Saururus chinensis (Saururaceae), Streptocaulon griffithii (Asclepiadaceae), Toddalia asiatica (Rutaceae) and Tadehagi triquetrum (Leguminosae).

Description

technical field [0001] The present invention relates to a new whitening agent and an external skin preparation for whitening containing the whitening agent, in particular to an external skin preparation for whitening which can effectively inhibit melanin production and prevent and improve pigmentation such as age spots and freckles. Background technique [0002] It is generally believed that hyperpigmentation of the skin such as age spots and freckles is caused by excessive formation of melanin due to abnormal secretion of hormones, ultraviolet rays, local skin inflammation, etc., and the melanin is deposited in the skin. Melanin, which is the cause of skin pigmentation, is produced in organelles called melanosomes in pigment cells (melanocytes) present in the basal layer of the epidermis, and the produced melanin is absorbed by surrounding keratinocytes ( Keratinocyte) surrounded. The production process of melanin in the melanin body is as follows, that is, tyrosine is oxi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61Q19/02
CPCA61K8/97A61Q19/02A61K8/9789A61K2800/80
Inventor 前田宪寿绳村刚小林孝次陈暖
Owner SHISEIDO CO LTD
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