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Application for polysaccharide extraction of grateloupia filicina in preparing antitumor medicine and other medicines

A kind of centipede algae polysaccharide, extract technology, applied in anti-AIDS and/or anti-tumor drug, its preparation, preparation of anticoagulant, centipede algae polysaccharide extract, antithrombotic field

Inactive Publication Date: 2007-11-28
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are no literature reports on the structure and antitumor activity of centipede algal polysaccharides, anti-HIV-1 virus, antithrombotic and anticoagulant activities

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 9

[0025] (6) Effect of intravenous injection of GFP on inferior vena cava thrombosis (embodiment 10)

[0026] (7) Effect of oral GFP on inferior vena cava thrombosis (embodiment 11)

[0027] (8) centipede algal polysaccharide is to HIV-1 virus inhibitory effect (embodiment 12)

[0028] A pharmaceutically acceptable carrier can be added to the centipede polysaccharide extract to facilitate its administration. Preferably, the pharmaceutical composition of the present invention contains 0.1-99.9% by weight of the extract. The "pharmaceutically acceptable carrier" will not destroy the pharmaceutical activity of the centipede algal polysaccharide extract, and its effective dosage, that is, the dosage when it can function as a drug carrier, is non-toxic to the human body.

[0029] "Pharmaceutically acceptable carriers" include, but are not limited to: ion exchange materials, alumina, aluminum stearate, lecithin, self-emulsifying drug delivery systems (SEDDS) such as d-alpha-tocopher...

Embodiment 1

[0039] Example 1 Preparation of centipede algal polysaccharide extract A

[0040] 300 g of centipede algae was pulverized, and then extracted by adding 6 liters of 90°C water for 1 hour, during which time glacial acetic acid was added to control the pH value of the extract to 6.2. Centrifuge to obtain 5 liters of supernatant, add 15 liters of 95% ethanol under stirring, centrifuge, and discard the supernatant. The precipitate was dissolved in 3 liters of water, and freeze-dried to obtain 10 g of centipede polysaccharide (A extract).

Embodiment 2

[0041] Example 2 Preparation of centipede algal polysaccharide extract B

[0042] 1.5 kg of centipede algae was pulverized, and then 50 liters of boiling water was added to extract for 2 hours, during which time glacial acetic acid was added to control the pH value of the extract to 6.8. The supernatant obtained by centrifugation was concentrated to 30 liters, and 60 liters of 95% ethanol was added under stirring, and the supernatant was discarded after centrifugation. The precipitate was dissolved in 10 liters of water, and 60 g of freeze-dried centipede polysaccharide (B extract).

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PUM

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Abstract

The present invention relates to the application of one kind of Granteloupia cuminata polysaccharide extract in preparing medicine for treating blood coagulation, thrombus, AIDS and / or tumor, and provides its preparation process.

Description

Technical field: [0001] The invention belongs to the technical field of traditional Chinese medicine. It specifically relates to a plant extract, in particular to a centipede algal polysaccharide extract, its preparation method and its use in the preparation of anticoagulant, antithrombotic, anti-AIDS and / or antitumor drugs. Background technique [0002] Cardiovascular and cerebrovascular diseases and tumors are the two most serious threats to human health. At present, there are many drugs for these two types of diseases clinically, but they usually have certain toxic and side effects. For example, the anticoagulant drug heparin, which has been clinically used for many years, is a good anticoagulant drug. At the same time, it also has a good effect as an angiogenesis inhibitor in the treatment of tumors. But its biggest disadvantage is that it often causes uncontrollable bleeding, which limits its wider application. At present, scientists are trying to solve it in two wa...

Claims

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Application Information

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IPC IPC(8): A61K36/02A61K31/715A61P35/00A61P7/02A61P9/10A61P31/18
Inventor 王顺春施松善周吉燕王峥涛胡之璧
Owner SHANGHAI UNIV OF T C M
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