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Method for preparing 'kelike' capsule

A technology of Keli Ke capsule and Li Ke capsule, which is applied in the fields of capsule delivery, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve problems affecting the uniformity of the preparation content and large content differences.

Inactive Publication Date: 2007-10-24
杨文龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, in the application of the preparation of Kelike capsules, there is a problem that is often faced with content uniformity, because there are 5 components in the drug prescription, and the amount of acetaminophen with the highest content is as much as maleic acid 125 times that of chlorpheniramine, and amantadine hydrochloride is 50 times that of chlorpheniramine maleate. The contents of these five are quite different, and the static electricity generated when substances with completely different chemical and physical properties are mixed often affects the content of the preparation Evenness

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Prescription: Acetaminophen 2500g Amantadine Hydrochloride 1000g

[0019] Artificial Bezoar 100g Caffeine 150g

[0020] Chlorpheniramine maleate 20g 5% starch slurry appropriate amount

[0021] Magnesium Stearate 1.5g

[0022] Makes 10,000 capsules

[0023] Preparation method: Acetaminophen, chlorpheniramine maleate, amantadine hydrochloride, artificial bezoar and caffeine are fully mixed (the mixing tank is grounded), and sieved; the sieve used is a metal material sieve, and the metal material is sieved when sieving The sieve is grounded to remove static electricity. The aperture of the metal sieve is 80 meshes. Starch slurry is added to granulate, mixed with magnesium stearate to fill capsules, and the product is obtained.

Embodiment 2

[0025] Prescription: Acetaminophen 2500g Amantadine Hydrochloride 1000g

[0026] Artificial Bezoar 100g Caffeine 150g

[0027] Chlorpheniramine maleate 20g 5% starch slurry appropriate amount

[0028] Magnesium Stearate 1.5g

[0029] Makes 10,000 capsules

[0030] Preparation method: Acetaminophen, chlorpheniramine maleate, amantadine hydrochloride, artificial bezoar and caffeine are fully mixed (the mixing tank is grounded), and sieved; the sieve used is a metal material sieve, and the metal material is sieved when sieving The sieve is grounded to discharge static electricity, the aperture of the metal material sieve is 100 mesh, starch slurry is added to granulate, mixed with magnesium stearate to fill capsules, and the product is obtained.

Embodiment 3

[0032] Prescription: Acetaminophen 2500g Amantadine Hydrochloride 1000g

[0033] Artificial Bezoar 100g Caffeine 150g

[0034] Chlorpheniramine maleate 20g 5% starch slurry appropriate amount

[0035] Magnesium Stearate 1.5g

[0036] Makes 10,000 capsules

[0037] Preparation method: Acetaminophen, chlorpheniramine maleate, amantadine hydrochloride, artificial bezoar and caffeine are fully mixed (the mixing tank is grounded), and sieved; the sieve used is a metal material sieve, and the metal material is sieved when sieving The sieve is grounded to discharge static electricity, the aperture of the metal material sieve is 120 meshes, starch slurry is added to granulate, mixed with magnesium stearate to fill capsules, and the product is obtained.

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Abstract

The invention discloses a process for preparing compound paracetamot and amantadine lydrochloide capsules for treating common cold, wherein each tablet of the compound paracetamot and amantadine lydrochloide capsules comprises acetaminopher 250mg, amantadine hydrochloride 100mg, artificial ox gallstone 10mg, caffeine 15mg, chlorpheniramine maleate 2mg.

Description

【Technical field】 [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a preparation method of Kelike capsules. 【Background technique】 [0002] Kelike Capsules (Compound Amantadine Capsules) is a commonly used cold medicine produced by Renhe Group. Its unit preparation contains 250 mg of paracetamol, 100 mg of amantadine hydrochloride, 10 mg of artificial bezoar, caffeine 15 mg, chlorpheniramine maleate 2 mg; after long-term clinical verification, Keli Ke capsule has become one of the first choice drugs for cold treatment. [0003] Acetaminophen in Kelike Capsules has antipyretic and analgesic effects, and its mechanism of action is to inhibit the synthesis and release of prostaglandin (PGE2) in the hypothalamic thermoregulation center to cause peripheral blood vessel dilation, causing sweating to achieve antipyretic At the same time, it can inhibit the effects of bradykinin, etc., and increase the pain threshold t...

Claims

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Application Information

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IPC IPC(8): A61K35/413A61K9/48A61P31/00A61P29/00A61P11/00A61K31/13A61K31/167A61K31/4402A61K31/522
Inventor 杨文龙
Owner 杨文龙
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