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Method for preparing 'youkadan' granule

A technology of eucardium and granules, which is applied to medical preparations containing active ingredients, pharmaceutical formulations, and devices that make medicines into special physical or taking forms, etc., can solve the problem of large content differences and affect the content uniformity of preparations And other issues

Inactive Publication Date: 2007-10-24
杨文龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, in the formulation application of Eucadan Granules, a problem that is often faced is content uniformity, because there are 5 components in the drug prescription, and the amount of acetaminophen with the highest content is as much as maleic acid 125 times that of chlorpheniramine, and amantadine hydrochloride is 50 times that of chlorpheniramine maleate. The contents of these five are quite different, and the static electricity generated when substances with completely different chemical and physical properties are mixed often affects the content of the preparation Evenness

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Prescription: Acetaminophen 1000g Amantadine Hydrochloride 400g

[0019] Artificial Bezoar 40g Caffeine 60g

[0020] Chlorpheniramine maleate 8 grams 5% starch slurry appropriate amount

[0021] Magnesium Stearate 0.8g Sucrose 45000g

[0022] Made into 10000 bags

[0023] Preparation method: Acetaminophen, chlorpheniramine maleate, amantadine hydrochloride, artificial bezoar and caffeine are fully mixed (the mixing tank is grounded), and sieved; the sieve used is a metal material sieve, and the metal material is sieved when sieving The sieve is grounded to discharge static electricity. The aperture of the metal sieve is 80 meshes. Add starch slurry to granulate, mix sucrose and magnesium stearate, and pack granules separately to obtain the product.

Embodiment 2

[0025] Prescription: Acetaminophen 1000g Amantadine Hydrochloride 400g

[0026] Artificial Bezoar 40g Caffeine 60g

[0027] Chlorpheniramine maleate 8 grams 5% starch slurry appropriate amount

[0028] Magnesium Stearate 0.8g Sucrose 45000g

[0029] Made into 10000 bags

[0030] Preparation method: Acetaminophen, chlorpheniramine maleate, amantadine hydrochloride, artificial bezoar and caffeine are fully mixed (the mixing tank is grounded), and sieved; the sieve used is a metal material sieve, and the metal material is sieved when sieving The sieve is grounded to discharge static electricity. The aperture of the metal sieve is 100 meshes. Add starch slurry to granulate, mix sucrose and magnesium stearate, and pack granules separately to obtain the product.

Embodiment 3

[0032] Prescription: Acetaminophen 1000g Amantadine Hydrochloride 400g

[0033] Artificial Bezoar 40g Caffeine 60g

[0034] Chlorpheniramine maleate 8 grams 5% starch slurry appropriate amount

[0035] Magnesium Stearate 0.8g Sucrose 45000g

[0036] Made into 10000 bags

[0037] Preparation method: Acetaminophen, chlorpheniramine maleate, amantadine hydrochloride, artificial bezoar and caffeine are fully mixed (the mixing tank is grounded), and sieved; the sieve used is a metal material sieve, and the metal material is sieved when sieving The sieve is grounded to discharge static electricity. The aperture of the metal material sieve is 120 meshes. Add starch slurry to granulate, mix sucrose and magnesium stearate, and pack granules separately to obtain the product.

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Abstract

The invention discloses a process for preparing pediatric paracetamol and amantadine hydrochloride granules for treating children's common cold, wherein each unit of the preparation comprises Paracetamol 100mg, amantadine hydrochloride 40mg, artificial ox gallstone 4mg, caffeine 6mg and chlorpheniramine maleate 0. 8mg.

Description

【Technical field】 [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a method for preparing Eucadan granules. 【Background technique】 [0002] Youkadan Granules (i.e. Pediatric Compound Amantadine Granules) is a common cold medicine for children produced by Renhe Group. Its unit preparation contains 100 mg of acetaminophen, 40 mg of amantadine hydrochloride, 4 mg of artificial bezoar, Caffeine 6 mg, chlorpheniramine maleate 0.8 mg; Eucadan granules have become one of the first choice drugs for children's cold treatment after long-term clinical verification. [0003] The acetaminophen in Youkadan Granules has antipyretic and analgesic effects, and its mechanism of action is to inhibit the synthesis and release of prostaglandin (PGE2) in the hypothalamic thermoregulation center to cause peripheral blood vessel dilation and cause sweating to achieve antipyretic At the same time, it can inhibit the effects of bradykin...

Claims

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Application Information

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IPC IPC(8): A61K35/413A61K9/16A61J3/00A61P31/00A61P29/00A61P11/00A61K31/13A61K31/167A61K31/4402A61K31/522
Inventor 杨文龙
Owner 杨文龙
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