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Environment protection vehicular HPLC instrument

An environmentally friendly and environmentally friendly device technology, applied in the direction of instruments, scientific instruments, measuring devices, etc., can solve the problem of unsuitable mobile laboratory use, and achieve the effect of miniaturization and complete machine, fast operation, and shortening time.

Active Publication Date: 2010-07-14
NAT INST FOR THE CONTROL OF PHARMA & BIOLOGICAL PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the current high-performance liquid chromatography (HPLC) instrument is not suitable for use in mobile laboratories (drug testing vehicles)

Method used

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  • Environment protection vehicular HPLC instrument
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  • Environment protection vehicular HPLC instrument

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0054] In order to investigate the influence of the environment-friendly vehicle-mounted HPLC instrument of the present invention on the detection method and the experimental results, the researchers of the present invention conducted experiments on the qualitative and quantitative methods of hypoglycemic drugs in a closed system.

[0055] 1. Investigation of the reference substance solution

[0056] Mobile phase composition: Methanol-0.01mol / l KH 2 PO 4 Buffer (adjust the pH to 3.0 with phosphoric acid) (70:30). Mobile phase volume: 500ml.

[0057] Sample: glipizide, gliclazide, glibenclamide, glimepiride, glipizide, repaglinide and a mixture of six reference solutions (both methanol sample preparation), the reagent blank is Methanol.

[0058] The airtight environmental protection device was used to circulate for 82 hours, and the volume of each injection was 10 μl, a total of 224 needles, and the flow rate was 1.0ml / min; the total volume of injection was 2.375ml (includi...

experiment example 2

[0071] The using method of environment-friendly vehicle-mounted HPLC instrument of the present invention is:

[0072] 1. Sample processing method: Take the smallest package (1 piece / grain / bottle / bag), put it in containers of different volumes according to different specifications, add organic solvent or water to dissolve according to the nature of the sample, and if necessary, ultrasonically assist dissolution, filter After that, it was used as the test solution; the reference solution was prepared in the same way, and the two were injected sequentially.

[0073] 2. If the chromatogram of the obtained test product is inconsistent with the chromatogram of the reference substance, then the product is a fake drug; Figure 1 (the retention times of the chromatographic peaks are the same) and the ultraviolet spectrograms obtained by the diode array detector are also consistent, then it can be considered that the tested sample contains active ingredients, and then the reference subs...

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Abstract

The environment friendly vehicular HPLC instrument includes a transfer pump, a sample injector, a chromatographic column, a detector and a data processing system connected successively, as well as an environment friendly sealed flow phase device connected to the transfer pump and the detector. The environment friendly sealed flow phase device includes one sealed container, one liquid inlet pipe, and one liquid replenishing pipe. The environment friendly vehicular HPLC instrument is used in HPLC identification and content measurement in a movable lab. It has the liquid exhausting pipe of high performance liquid chromatograph set inside the flow phase storing bottle to form one circulating system, and has environment friendship and saving in flow phase.

Description

technical field [0001] The invention relates to a high-performance liquid chromatography system, in particular to an environment-friendly vehicle-mounted HPLC instrument, which belongs to the field of drug detection. Background technique [0002] The manufacture and sale of counterfeit and substandard drugs and the resulting problems are worldwide. According to World Health Organization estimates, the annual global production of counterfeit medicines is as high as 80 billion francs, and 65% of counterfeit medicine incidents occur in developing countries. 80% of the illegal activities of manufacturing and selling counterfeit and inferior drugs in my country occur in the vast rural areas, where there are many rural medical institutions, small in scale and most of them are located in remote areas. In the field of circulation, there are tens of thousands of drug varieties, but less than half of them are effectively supervised by the drug inspection department, and counterfeit p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
Inventor 金少鸿姚静胡昌勤张启明
Owner NAT INST FOR THE CONTROL OF PHARMA & BIOLOGICAL PROD
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