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Antibiosis rare earth ternary complexes and preparation method and application thereof

A ternary complex and rare earth technology, applied in the field of antibacterial materials, can solve the problems of narrow range of antibacterial materials, weak antibacterial effect, no application of antibacterial activity, etc., and achieve good chemical stability, thermal stability, and antibacterial effect Visible, strong antibacterial effect

Inactive Publication Date: 2007-09-26
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is to provide a kind of antibacterial rare earth ternary complex and its preparation method and application, to overcome the existing antibacterial material category limitation range is narrow, antibacterial effect is not strong, existing Ln rare earth nitrate and 2- Hydroxy-1-naphthyl methionine salt and o-phenanthroline ternary complexes have no antibacterial activity and application defects

Method used

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  • Antibiosis rare earth ternary complexes and preparation method and application thereof
  • Antibiosis rare earth ternary complexes and preparation method and application thereof
  • Antibiosis rare earth ternary complexes and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0046] Under the condition of heating and refluxing in a water bath at 50°C, add a certain amount of Schiff base ligand and add absolute ethanol to dissolve it, and slowly add RECl with a molar ratio of 1:2 to the Schiff base ligand under constant stirring. 3 ·xH 2 O (in advance by RE 2 o 3 reacted with hydrochloric acid), reacted under the above conditions for 2 hours, added the dehydrated ethanol solution of o-phenanthroline with an equimolar number of Schiff base ligands, continued to react for 4 hours, cooled to room temperature and suction filtered , the filtrate was concentrated to 12mL, a large number of yellow precipitates were formed when diethyl ether was added, filtered with suction, and the precipitates were washed with diethyl ether for 3 to 4 times to obtain RE(L)(A)(H 2 O), the resulting complex was vacuum-dried at room temperature at 50° C. for 2 h and then sealed and stored.

[0047] In the above method, L is Schiff base salicylaldehyde phenylalanine or Sch...

Embodiment 2

[0050] Under the condition of heating and refluxing in a water bath at 65°C, add a certain amount of Schiff base ligand and add absolute ethanol to dissolve it, and slowly add RECl with a molar ratio of 1:2 to the Schiff base ligand under constant stirring. 3 ·xH 2 O (in advance by RE 2 o 3 prepared by reacting with hydrochloric acid), reacted for 2.5 hours under the above-mentioned reaction conditions, added an absolute ethanol solution of a heterocyclic compound having an equimolar number of Schiff base ligands, continued to react for 3 hours, cooled to room temperature, and suction filtered. Concentrate the filtrate to 10mL, add diethyl ether to form a large amount of yellow precipitate, filter with suction, wash the precipitate with diethyl ether 3 to 4 times to obtain RE(L)(A)(H 2 O), the resulting complex was vacuum-dried at room temperature at 45° C. for 3 h and then sealed and stored.

[0051] Note: L is Schiff base salicylaldehyde phenylalanine or Schiff base salic...

Embodiment 3

[0054] The various complexes prepared in Examples 1 and 2 were tested for minimum inhibitory concentration respectively, and the data are as follows: the MIC result data of the complex to Escherichia coli is in the range of 30ppm~65ppm, and the MIC result data to Staphylococcus aureus is in the range of 100ppm ~300ppm range (the smaller the MIC, the better the antibacterial effect).

[0055] The result shows that the MIC of the obtained complex is much lower than the regulation of antibacterial agent MIC<800ppm stipulated in the chemical industry standard of the People's Republic of China, and the antibacterial effect is obvious.

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Abstract

The invention discloses a making method of antibiotic rare-earth ternary complex and application in the antibiotic material, whose chemical formula is RE (L) (A) (H2O), wherein RE is selected from one or more of La3+, Ce3+, Pr3+, Nd3+, Sm3+, Eu3+, Y3+, Er3+ or Gd3+; L is schiff bases salicylal anphenylalanine or schiff bases salicylal anaspartic acid; A is ortho-phenanthroline or pyridine.

Description

technical field [0001] The invention belongs to the technical field of antibacterial materials, and in particular relates to an antibacterial material of a rare earth ternary complex and a preparation method and application thereof. Background technique [0002] The core component of antibacterial agents is antibacterial materials. Antibacterial materials are chemical components that are highly sensitive to some bacteria, molds and other microorganisms. A very small amount of antibacterial material is added to ordinary materials to make antibacterial agents. Antibacterial agents can be classified into several categories such as organic, inorganic and natural. Organic antibacterial agents have strong antibacterial power and rapid antibacterial, but they have disadvantages such as poor heat resistance, easy hydrolysis, easy bacterial resistance and short service life. Inorganic antibacterial agents have the advantages of safety, heat resistance, and durability, and are suit...

Claims

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Application Information

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IPC IPC(8): C07F5/00A01N55/02A01P3/00
Inventor 何其庄马树芝李轶嘉郑文捷
Owner SHANGHAI NORMAL UNIVERSITY
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