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Nanometer antiviral liposome medicine and its preparation

A nanoliposome and drug technology, applied in antiviral agents, liposome delivery, pharmaceutical formulations, etc., can solve the problems of adverse reactions, low oral bioavailability, etc., to avoid relapse, improve blood circulation and Microcirculation, lowering blood lipids

Inactive Publication Date: 2010-12-01
江苏德伦生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the existing adefovir dipivoxil has gradually exposed the following deficiencies in clinical practice: the oral bioavailability is not high, adverse reactions, especially the safety issues of liver and kidney adverse reactions in patients need to be solved or improved

Method used

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  • Nanometer antiviral liposome medicine and its preparation
  • Nanometer antiviral liposome medicine and its preparation
  • Nanometer antiviral liposome medicine and its preparation

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Abstract

The present invention relates to one kind of nanometer antiviral liposome medicine and its preparation process. The nanometer antiviral liposome medicine includes the mixture of alprostadil and Adefovir dipivoxil in the weight ratio of 0.1-1.0 to 50-300 in 10.1-80.2 weight portions, soybean lecithin 88-440 weight portions, the mixture of cholesterol and soyasterol in the weight ratio of 9 to 1 in40-200 weight portions, the mixture of polyglycol-4000 and polyglycol-2000 in the same ratio in 15-40 weight portions, sodium glucuronate in 100-280 weight portions, vitamin C in 160-800 and glutathione in 5-10 weight portions. The nanometer antiviral liposome medicine is used as the broad spectrum antiviral medicine.

Description

Antiviral nano liposome drug and preparation method thereof technical field The invention relates to a broad-spectrum antiviral nano-liposome medicine and a preparation method thereof. Background technique Adefovir dipivoxil (adeforirdipiroxil), chemical name [[2-(6-amino-9H-purin-9-yl) ethoxy] methyl] phosphate bis-(pivaloyloxymethyl) ester, is The nucleoside virus inhibitor developed by Gileadsciences in the United States was first launched in the United States in 2002 under the trade name Hepsera, which has broad-spectrum antiviral activity. Its antiviral spectrum includes: anti-HIV-I and HIV-II AIDS virus, anti-hepatitis B virus HBV, and has a good effect on derived HBV and lamivudine-resistant HBV, and anti-herpes virus HSV- Type I and HSV-II type herpes simplex virus, anti-HIV co-infected cytomegalovirus, anti-Epstein-Barr virus, anti-moloney mouse sarcoma virus, also has the prospect of anti-other heterogeneous viruses. It is a drug with broad market prospect. H...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K47/24A61K31/5575A61K9/19A61K9/48A61K31/675A61P31/12A61K9/00A61K9/20A61K47/42A61K9/127A61K47/20A61K47/28
Inventor 蔡海德
Owner 江苏德伦生物制药有限公司
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