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A medicine composition for treating peptic ulcer, preparing method and use thereof

A composition and ulcer disease technology, which is applied in the direction of drug combination, medical formula, medical preparations containing active ingredients, etc., can solve the problems of unseen drugs, achieve clear drug ingredients, complementary therapeutic effects, and broad application prospects Effect

Inactive Publication Date: 2007-08-01
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no drug that has been made into the market
At present, there is no relevant report on preparations prepared only from Akiras arboriflora and Hippophae rhamnoides as raw materials, and there are no reports on drugs that use Akiras arboriflora extract and seabuckthorn oil as main active ingredients for the treatment of ulcers

Method used

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  • A medicine composition for treating peptic ulcer, preparing method and use thereof

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Embodiment 1

[0036] Embodiment 1 The preparation of the medicinal raw material of the present invention, the extract of Akiras chuanxiong

[0037] Akiba kawaii is crushed into coarse powder, and the extract of Akira kawaii is collected by supercritical fluid extraction, solvent ultrasonic extraction, solvent percolation extraction or solvent reflux extraction;

[0038] a. Cinnamon chrysalis is crushed into coarse powder, extracted and separated by supercritical fluid carbon dioxide, dried under reduced pressure at a temperature below 60° C., and the extract of Akira sichuanensis is collected.

[0039] b. Grind the chrysanthemum chrysanthemum into a coarse powder, add an appropriate amount of ethanol with a concentration of not less than 85%, soak it, extract it by ultrasonic vibration, recover the solvent under reduced pressure below 60°C, add water to suspend, extract with ethyl acetate, and recover under reduced pressure below 60°C Ethyl acetate, dry under reduced pressure below 60°C, an...

Embodiment 2

[0045] Example 2 Extraction of the pharmaceutical raw material seabuckthorn oil extract of the present invention

[0046] Seabuckthorn extraction method 1: take seabuckthorn fruit or seeds or a mixture of fruit and seeds, grind them, extract by solvent reflux, use n-heptane, heat and reflux extraction twice, each time for 4 hours, recover the solvent, and collect seabuckthorn oil extract ;

[0047] Extraction method 2 of seabuckthorn: take seabuckthorn fruit or seeds or a mixture of fruit and seeds and pulverize, extract with supercritical CO2 fluid, and collect seabuckthorn oil extract through a primary separator; wherein, the extraction pressure is 40 MPa, and the extraction temperature is 65 °C, the extraction flow rate is 18L / h, the primary separation pressure is 6.5MPa, and the primary separation temperature is 36°C.

[0048] Extraction method three of seabuckthorn: squeeze and centrifuge extraction:

[0049] Seabuckthorn fruits or seeds or a mixture of fruits and seeds...

Embodiment 3

[0050] Embodiment 3 The preparation of medicine dropping pill of the present invention

[0051] Take 180g of Chuanxiang extract and 150g of seabuckthorn oil extract, add them to 670g of poloxamer-polyethylene glycol-6000 (1:3) heated and melted, stir evenly, transfer to the dropping pill machine at 60-70 Under the condition of heat preservation at ℃, drop into simethicone oil at 10 ℃, collect the formed drop pills, deoil them, and make 1000g drop pills, to get final product.

[0052] Oral administration, three times a day, 1g each time, each 1g drop pill contains 180mg of Chuanxiang extract and 150mg of seabuckthorn oil extract.

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Abstract

The invention discloses a pharmaceutical composition for treating ulcer, which is prepared from vladimiria root and seabuckthorn fruit oil as the raw materials. The invention also provides the method for preparation and use of the pharmaceutical composition.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating or preventing ulcer disease, in particular relates to a medicine prepared from arborina officinalis and Hippophae rhamnoides as raw materials, and belongs to the field of medicines. Background technique [0002] Most peptic ulcers occur in the stomach or duodenum, referred to as ulcer disease for short. The clinical manifestations are mainly abdominal pain, which is limited to the upper abdomen. It has three characteristics: chronic, periodic and rhythmic. It is manifested as a long course of disease, repeated changes, and frequent complications, which seriously affect people's work and quality of life. [Lu Xinghua, Yu Zhonglin, Jiang Hongzhi, et al. Epidemiological Study of Ulcer Disease - Gastroscopy Analysis of 358,644 Cases in Beijing Area. Chinese Journal of Digestion. 1996, 16: 152]. Modern medicine believes that the main causes of ulcer disease are hyperacidity and Helicobacter ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P1/04
Inventor 赖先荣孟宪丽张艺王战国古锐
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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