Compound berberine sulphate injection and its preparation method

A technology for preparation of berberine sulfate and injection, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, active ingredients of heterocyclic compounds, etc. It can solve side effects such as mild gastrointestinal tract reactions, decreased efficacy of antibacterial drugs, Eliminate drug resistance, shorten drug withdrawal period, and increase weight due to long drug withdrawal period

Inactive Publication Date: 2007-08-01
TIANJIN SHENGJI GRP CO LTD
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Due to the wide application of antibacterial drugs, drug-resistant strains of Shigella are gradually increasing, and the curative effect of commonly used antibacterial drugs is significantly reduced. Quinolones: have a strong killing effect on Shigella, and have no cross-resistance with other antibacterial...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1 (every part is 500g):

[0017] Compound berberine sulfate injection: 5 parts of berberine sulfate, 10 parts of dysentery net, 5 parts of trimethoprim lactate, 0.5 part of atropine.

[0018] Compound berberine sulfate injection is made by the following method:

[0019] (1) Take by weight 5 parts of berberine sulfate, 10 parts of dysentery net, 5 parts of trimethoprim lactate, 0.5 part of atropine;

[0020] (2) Add the berberine sulfate into hot water for injection, stir until it is clear, and obtain solution A;

[0021] (3) Add the dysentery to solution A at 40-50°C, add 1 part of nicotinamide, stir until clear, and obtain solution B;

[0022] (4) Add the trimethoprim lactate and atropine to solution B and stir, and use 10% H 2 SO 4 Adjust pH4.0-6.0;

[0023] (5) Add 0.1% activated carbon to the solution, stir and adsorb for 15-20 minutes, add water for injection to 1000 parts, and then make compound berberine sulfate injection.

Embodiment 2

[0024] Embodiment 2 (every portion is 1500g):

[0025] Compound berberine sulfate injection: 25 parts of berberine sulfate, 35 parts of dysentery net, 25 parts of trimethoprim lactate, 1.5 parts of atropine.

[0026] Made in the following way:

[0027] (1) Take by weight 25 parts of berberine sulfate, 35 parts of dysentery net, 25 parts of trimethoprim lactate, 1.5 parts of atropine;

[0028] (2) Add the berberine sulfate into hot water for injection, stir until it is clear, and obtain solution A;

[0029] (3) Add the dysentery to solution A at 40-50°C, add 3.5 parts of nicotinamide, stir until clear, and obtain solution B;

[0030] (4) Add the trimethoprim lactate and atropine to solution B and stir, and use 10% H 2 SO 4 Adjust pH4.0-6.0;

[0031] (5) Add 0.1% activated carbon to the solution, stir and adsorb for 15-20 minutes, add water for injection to 1000 parts, and then make compound berberine sulfate injection.

Embodiment 3

[0032] Embodiment 3 (every portion is 500g):

[0033] Compound berberine sulfate injection: 20 parts of berberine sulfate, 20 parts of Shigaojing, 20 parts of trimethoprim lactate, 2 parts of atropine.

[0034] is made in the following way:

[0035] (1) Take by weight 20 parts of berberine sulfate, 20 parts of dysentery net, 20 parts of trimethoprim lactate, 2 parts of atropine;

[0036] (2) Add the berberine sulfate into hot water for injection, stir until it is clear, and obtain solution A;

[0037] (3) Add the dysentery to solution A at 40-50°C, add 2 parts of nicotinamide, stir until clear, and obtain solution B;

[0038] (4) Add the trimethoprim lactate and atropine to solution B and stir, and use 10% H 2 SO 4 Adjust pH4.0-6.0;

[0039] (5) Add 0.1% activated carbon to the solution, stir and adsorb for 15-20 minutes, add water for injection to 1000 parts, and then make compound berberine sulfate injection.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention disclosed a kind of compound sulphuric acid berberine injection as well as its preparing method. The compound sulphuric acid berberine injection includes the following ingredients: 5-30 shares of suphuric acid berberine, 5-35 shares of mequindox, 1-25 shares of lactic acid trimethoprim and 0.5-2 shares of atrop; the preparing procedure includes the following steps: weighting ingredients; putting mequindox into the water for injection at 40-50DEG C; adding certain amount of auxiliary solvent, stirring for 10min to the solution is clear; putting lactic acid trimethoprim and atrop I to the previous solution, stirring and regulating the pH value; putting activated char into the solution and stirring for 15-20min, adding water for injection to 1000 shares to get the product. The invention can be widely used to treat the diarrhea caused by swine dysentery bacilli, increase its immunity and increase the body weights.

Description

technical field [0001] The invention relates to the field of drug injections, in particular to a compound berberine sulfate injection and a preparation method thereof. Background technique [0002] Due to the wide application of antibacterial drugs, drug-resistant strains of Shigella are gradually increasing, and the curative effect of commonly used antibacterial drugs is significantly reduced. Quinolones: have a strong killing effect on Shigella, and have no cross-resistance with other antibacterial drugs. Mild gastrointestinal reactions; most Shigella strains have developed resistance to chloramphenicol and tetracycline antibiotics, but there are few Shigella strains resistant to gentamicin, so gentamicin is one of the commonly used antibiotics at present , but there is a shortcoming of a long withdrawal period. Contents of the invention [0003] The purpose of the present invention is in order to expand the antibacterial range of medicine, and a kind of avoiding repeat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/505A61K31/4375A61P31/04A61P1/12A61K31/46
Inventor 魏宗生耿强斌郭建华
Owner TIANJIN SHENGJI GRP CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap