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Compounding Herba Andrographitis dripping pills, and its preparing method

A technology of lotus dripping pills and andrographis paniculata, applied in the directions of pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc. Labor protection and environmental protection, high bioavailability, good drug stability

Inactive Publication Date: 2007-07-25
陈茜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the characteristics of conventional tablet preparation technology, such oral preparations have long disintegration time, poor absorption, slow onset of action, and low bioavailability, which affect the full play of drug efficacy.
At the same time, it is easy to split, change color, absorb moisture, etc. during storage, and the quality is unstable

Method used

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  • Compounding Herba Andrographitis dripping pills, and its preparing method
  • Compounding Herba Andrographitis dripping pills, and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: Get 900g of Andrographis paniculata and 2100g of Lubianqing, add water to decoct twice, the amount of water added is 8 times the amount for the first time, 6 times the amount for the second time, and the decoction time is 2 hours for the first time and 1 hour for the second time , combined the decoction, let it stand for 12 hours, filtered, the filtrate was concentrated to an extract with a relative density of 1.16-1.26 (60°C), added ethanol to make the alcohol content 70%, stirred evenly, stood for 24 hours, and took the above Ethanol is recovered from the clear liquid, concentrated into an extract, and the extract is vacuum-dried to obtain an extract. Take the extract, crush it, and pass through a 100-mesh sieve. Andrographis paniculata, roadside green extract by weight: polyethylene glycol 6000 =1:2 ratio, add to the melted matrix (87°C), stir evenly, drop into the simethicone coolant (3°C), separate the dropping pills, absorb the coolant, and dry to o...

Embodiment 2

[0020] Embodiment two: get the extract of embodiment one, pulverize, cross 100 mesh sieves. Andrographis paniculata, roadside green extract by weight: the ratio of mixed matrix=1: 2 (mixed matrix is ​​polyethylene glycol 6000 : poloxamer according to 1:0.2 formula), add to the melted mixed matrix (87°C), stir evenly, drop into the simethicone coolant (3°C), separate the dropping pills, absorb the coolant , dried, that is.

Embodiment 3

[0021] Example 3: In this example, through the extracts of Andrographis paniculata and Lubianqing and different matrix formulations, the indicators such as roundness, difference in pill weight, hardness, and dissolution time are investigated to determine the weight ratio of the extract to a single or mixed matrix.

[0022] Andrographis paniculata, Lubianqing extracts and different matrix formulation tests (extracts are 1 part)

[0023] Note: The coolant is simethicone oil or liquid paraffin, and the cooling temperature is 1-5°C; the temperature of the heat preservation of the drug material and the dripper is 85-90°C; the dripping speed is 30-50 capsules / minute.

[0024] The above results show that all the indicators of No. 4, 5, 6, 7, and 8 tests are good, that is, when the ratio of the extract to the matrix is ​​1:1-1:5, it can be dripped smoothly. However, considering the dosage and other factors, the preferred ratio is Test Nos. 4, 5, 6, and 8, that is, the ratio of the...

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PUM

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Abstract

A dripping pill of green chiretta for treating cold, tonsillitis, enteritis and urethritis is prepared from green chiretta and matrix. Its preparing process is also disclosed.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a compound Chuanxinlian dripping pill and a preparation process thereof. Background technique [0002] Infectious diseases are most common with bacterial infection and viral infection. According to TCM syndrome differentiation, acute infection is mostly heat-toxin syndrome, which can be treated with traditional Chinese medicine for clearing away heat and detoxifying. Compound Andrographis paniculata preparation is an antibacterial and anti-inflammatory compound Chinese patent medicine, which is composed of Andrographis paniculata and Lubianqing, and has antibacterial, antiviral and anti-inflammatory effects. Andrographis paniculata is mainly produced in Guangdong and Fujian, and it is now introduced and cultivated in the north and south of the Yangtze River. It has the functions of clearing away heat and detoxification, cooling blood, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/855A61K9/20A61P31/04A61P31/12
Inventor 陈茜滕慧丽
Owner 陈茜
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