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Dripping pills for treating laryngopathy, and its preparing method

A technology of Houshuning dropping pills and dropping pills, which is applied in the field of Houshuning dropping pills and its preparation, can solve the problems of unfavorable swallowing by patients with dysphagia, affecting the full effect of the drug, and low bioavailability. GMP management, beneficial to labor protection and environmental protection, high bioavailability effect

Inactive Publication Date: 2007-07-25
陈茜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the characteristics of conventional tablet preparation technology, such oral preparations have long disintegration time, poor absorption, slow onset of action, and low bioavailability, which affect the full play of drug efficacy.
At the same time, it is easy to split, change color, absorb moisture, etc. during storage, and the quality is unstable
It is also not suitable for patients with swallowing difficulties

Method used

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  • Dripping pills for treating laryngopathy, and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Take 1666g of Hedyotis diffusa, 1334g of Andrographis paniculata, and 1000g of wild sesame, add water to decoct twice, the amount of water added is 8 times the amount for the first time, and 6 times the amount for the second time, the decoction time is 1 hour each time, and the decoction is combined liquid, let it stand for 12 hours, filter, and concentrate the filtrate to an extract with a relative density of 1.14 to 1.24 (60°C), add ethanol to make the alcohol content 65%, stir evenly, let stand for 24 hours, and take the supernatant for recovery Ethanol, concentrated into an extract, and vacuum-dried the extract to obtain an extract. Take the extract, crush it, and sieve it. Extracts of Hedyotis diffusa, Andrographis paniculata, and Sesame by weight: polyethylene glycol 6000 =1:2.5 ratio, add to the melted matrix (87°C), stir evenly, drop into the simethicone coolant (3°C), separate the dripping pills, absorb the coolant, and dry to obtain.

Embodiment 2

[0020] Embodiment two: take the extract of embodiment one, pulverize, sieve. The ratio by weight is Hedyotis diffusa, Andrographis paniculata, Sesame extract: the ratio of mixed matrix=1:1.5 (the mixed matrix is ​​polyethylene glycol 6000 : poloxamer according to 1:0.3 formula), add to the melted mixed matrix (87 ℃), stir evenly, drop into the simethicone coolant (3 ℃), separate the dropping pills, absorb the coolant , dried, that is.

Embodiment 3

[0021] Example 3: In this example, through the formulation of Hedyotis diffusa, Andrographis paniculata, and Sesame extracts with different matrixes, the indicators of roundness, pill weight difference, hardness, and dissolution time are investigated to determine whether the extracts are compatible with a single or mixed matrix. weight ratio.

[0022] Experiments on the extracts of Hedyotis diffusa, Andrographis paniculata, and Sesame chinensis and different matrix formulations (1 part of each extract)

[0023] Note: 1. The coolant is simethicone oil or liquid paraffin, and the cooling temperature is 1-5°C; the heat preservation temperature of the medicinal material and the dripper is 85-90°C; the dripping speed is 30-50 capsules / min.

[0024] 2. The above results show that all the indicators of No. 4~11 experiments are good, that is, when the ratio of the extract to the matrix is ​​1:1~1:5, it can be dripped smoothly. However, considering the dosage and other factors, the ...

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PUM

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Abstract

A Chinese medicine 'Houshuning dripping pill' for treating pharyngolaryngitis, acute tonsillitis, polyp on vocal fold, neck cancer, etc is prepared from oldenlandia, green chiretta and screwtree root. Its preparing process is also disclosed.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a Houshuning dripping pill and a preparation process thereof. Background technique [0002] The throat is an important organ for swallowing food and pronunciation, and it is also one of the important organs of the human body. Due to certain factors, there have been many patients suffering from pharyngitis of varying degrees in recent years. Sore throat is a disease caused by viruses and bacteria. If the tonsils are inflamed, it is tonsillitis. The etiology of chronic pharyngitis is mainly due to the incomplete treatment of acute pharyngitis and recurrent outbreaks, which turn into chronic pharyngitis after a long time. Patients suffer from foreign body sensation in the throat, sore throat, red and swollen throat, dry throat, itchy throat, coughing, difficulty swallowing, hoarseness, and even aphonia. A large amount of medical research p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61K9/20A61P11/04
Inventor 陈茜滕慧丽
Owner 陈茜
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