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Nanometer liposome preparation containing emu oil, and its preparing method

A nano-liposome and nano-lipid technology, which is used in skin care preparations, cosmetic preparations, cosmetic preparations, etc., can solve the problems of inability to achieve the level of particle size nanoscale, stable preservation, fusion, and turbid preparations.

Inactive Publication Date: 2007-07-25
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Otherwise, it will be impossible to achieve the technical index requirements of particle size nanometerization and stable storage for more than one year, and undesirable phenomena such as fusion, flocculation, and precipitation of emu oil liposomes will occur, and the appearance of the preparation will be turbid, sedimentation, and emu oil seepage. Poor quality problems such as leakage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] According to 1000ml unit, the prescription is as follows:

[0024] Prescription one:

[0025] Emu Oil 50ml

[0026] Egg yolk lecithin (phospholipid purity 92%) 15.0g

[0027] Cholesterol (biochemical reagent) 5.0g

[0028] Tween 80 (analytical pure) 50ml

[0029] a-tocopherol (vitamin E, chemically pure) 0.5g

[0030] Glycerol (analytical pure) 25ml

[0031] Ethanol (analytical pure) 20ml

[0032] Add deionized water to 1000ml

[0033] Preparation process parameters: Nitrogen flow throughout the whole process; high-speed homogenization process parameters: rotation speed 16000 rpm, homogenization time 10min, control temperature 70°C; process control parameters in the high-pressure homogenization stage: working pressure 120MPa, cycle treatment times 6 times Control the temperature to 30°C.

[0034] Preparation sample appearance: clear transparent liquid.

[0035] Particle size detection method: dynamic laser light scattering method. Detection instrument: ZetaPAL...

Embodiment 2

[0038] According to 1000ml unit, the prescription is as follows:

[0039] Prescription two:

[0040] Emu Oil 80ml

[0041] Soybean yellow lecithin (phospholipid purity 92%) 20.0g

[0042] Cholesterol (pharmaceutical grade) 2.0g

[0043] a-tocopherol (vitamin E) 1.0g

[0044] Glycerol (analytical pure) 25ml

[0045] Ethanol (analytical pure) 10ml

[0046] Xanthan Gum 150g

[0047] Add 20g / L poloxamer 188 resin aqueous solution to 1000ml

[0048] Preparation process parameters: Nitrogen flow throughout the whole process; high-speed homogenization process parameters: rotation speed 12000 rpm, homogenization time 15min, control temperature 75°C; process control parameters in the high-pressure homogenization stage: working pressure 100MPa, cycle treatment times 9 times , control the temperature at 35°C.

[0049] Preparation sample appearance: clear transparent liquid.

[0050] Particle size detection method: dynamic laser light scattering method. Detection instrument: Zet...

Embodiment 3

[0053] According to 1000ml unit, the prescription is as follows:

[0054] Prescription three:

[0055] Emu Oil 30ml

[0056] Egg yolk lecithin (phospholipid purity 92%) 5.0g

[0057] Cholesterol (pharmaceutical grade) 1.0g

[0058] Tween 80 (chemically pure) 50ml

[0059] a-tocopherol (vitamin E, chemically pure) 0.52g

[0060] Glycerol (analytical pure) 20ml

[0061] Ethanol (analytical pure) 5ml

[0062] Add 20g / L polyvinylpyrrolidone aqueous solution to 1000ml

[0063] Preparation process parameters: Nitrogen flow throughout the whole process; high-speed homogenization process parameters: rotation speed 6000 rpm, homogenization time 10min, control temperature 65°C; process control parameters for high-pressure homogenization stage: working pressure 120MPa, cycle treatment times 2 times , control the temperature at 40°C.

[0064] Preparation sample appearance: clear transparent liquid.

[0065] Particle size detection method: dynamic laser light scattering method. Det...

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Abstract

A nano-liposome of emu fat in the form of transparent liquid is prepared from emu fat, lecithin, cholesterol, antioxidant, solubilizer, thickening agent and glycerin through proportioning, preparing oil phase and water phase, mixing, filling N2 to prepare dispersed emulsion, filling N2 while high-pressure homogenizing, and natural cooling.

Description

technical field [0001] The invention relates to a formulation of emu oil nano liposome preparation used in cosmetics and a preparation process thereof, belonging to the field of hygienic cosmetics. Background technique [0002] Emu oil is animal oil extracted from the fat pockets on the back of emu. Its oil has strong penetration and is easily absorbed by the skin. It has the effect of softening blood vessels and reducing triglycerides. It has long been called "sacred oil" by local Australians And "liquid gold", it has important application value in health food, clinical treatment of burns, and manufacture of advanced cosmetics. [0003] Scientific research has found that emu oil has excellent compatibility with skin structure, can effectively improve skin biological function, enhance skin elasticity, especially contains a large amount of unsaturated ethylenic acid, has strong skin penetration, and can obviously soften the skin The stratum corneum, smoothes wrinkles, remove...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61K8/98A61Q19/00A61Q19/08
Inventor 张小宁郝艳丽周迎
Owner TSINGHUA UNIV
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